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Effects of Mexiletine on Colonic Transit in a Patient With Irritable Bowel Syndrome - Constipation (IBS-C)

IBS Clinical Trial

Official title:
Effects of Mexiletine on Colonic Transit in a Patient With a Known SCN5A A997T Mutation

Clinical Trial Summary

To understand if Mexiletine will restores normal colonic motility in a patient with irritable bowel syndrome - constipation (IBS-C) and a genetic mutation in SCN5A.

Clinical Trial Description

To understand if Mexiletine will restore normal colonic motility in a patient with a missense mutation in SCN5A, which encodes a voltage-sensitive sodium channel NaV1.5 as it is known to rescue certain expression defects of NaV1.5 in vitro. ;

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01717404
Study type Interventional
Source Mayo Clinic
Contact
Status Completed
Phase Phase 1
Start date October 2012
Completion date November 2012
View Details
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