Ebastine Versus Mebeverine in IBS Patients

Status Recruiting

Clinical Trial Summary

Multicenter randomized controlled clinical trial comparing ebastine and mebeverine as treatment of irritable bowel syndrome Trial rationale 1. To perform a randomized superiority trial comparing the clinical efficacy of ebastine and mebeverine 2. To evaluate the impact of treatment with ebastine compared to mebeverine on quality of life and quality-adjusted life years Primary objective To provide further evidence of the superiority of histamine 1 receptor antagonism as novel treatment for patients with non-constipated IBS, as compared to mebeverine, one of the spasmolytics currently used as first line treatment of IBS. Secondary objective(s) To provide evidence that the histamine 1 receptor antagonist ebastine is more effective in reducing abdominal pain compared to the commonly used antispasmodic mebeverine

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05815602
Study type	Interventional
Source	KU Leuven
Contact	Koen Bellens, MSc.
Phone	+3216341943
Email	koen.bellens@kuleuven.be
Status	Recruiting
Phase	Phase 3
Start date	March 30, 2023
Completion date	January 1, 2027

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