Fecal Transplantation in Patients With IBS

Status Completed

Clinical Trial Summary

The study will characterize the biology of FMT in the context of IBS prior to wider clinical application of the method. Given the ethical concerns of unknown and long-term adverse effects of FMT therapy, the study will include patients only with moderate to severe symptoms. IBS is a heterogenous disorder and it is important to characterize the patients, and study as homogeneous patient populations as possible. Therefore the study will only include post-infectious IBS patients after the Giardia outbreak.

Clinical Trial Description

Primary aims:

Detailed characterisation of donor and recipient microbial community composition (by means of 16S rRNA profiling) and determination of the kinetics of changes following FMT

Secondary aims:

- Determination of interactions of importance to persisting recipient gut microbiota.

- Evaluate safety of FMT in an IBS population

- To evaluate the efficacy of FMT in relieving symptoms in selected patients with IBS in an open pilot trial in order to have the possibility to calculate number of patients needed when planning future controlled studies. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03333291
Study type	Interventional
Source	Haukeland University Hospital
Contact
Status	Completed
Phase	N/A
Start date	October 1, 2016
Completion date	June 30, 2017

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT05118243` - Innovative Tools to Produce Legume-based Foods for Increased Consumer Acceptance	N/A
Completed	`NCT04422327` - The Impact of a Combination of Bifidobacterium Longum 35624® and 1714™ Strains in Adults With Irritable Bowel Syndrome	Phase 1/Phase 2
Recruiting	`NCT05178017` - Lifestyle Eating and Performance (LEAP) Program for the Treatment of Irritable Bowel Syndrome (IBS)	N/A
Completed	`NCT05197413` - Study to Evaluate the Efficacy of Arrae's Bloat & Calm Alchemy Capsules to Reduce Bloating, Heartburn and Gas, and Alleviate the Intensity of IBS Symptoms	N/A
Completed	`NCT04905524` - Activity Changes in Irritable Bowel Syndrome (IBS), Anxiety, and Depression Following the Use of Viome Precision Nutrition Program (VPNP)	N/A
Recruiting	`NCT06297785` - Online, Gut-directed Hypnotherapy for Patients With Irritable Bowel Syndrome (IBS)	N/A
Recruiting	`NCT05874830` - The Optimal Route of Fecal Microbiota Transplantation for Irritable Bowel Syndrome	N/A
Active, not recruiting	`NCT04723056` - Zemedy Application for Irritable Bowel Syndrome	N/A
Completed	`NCT05565612` - Clinical Trial to Evaluate the Effect of a Probiotic Mixture on Signs and Symptoms of Irritable Bowel Syndrome	N/A
Recruiting	`NCT03131414` - The IMAGINE-SPOR CIHR Chronic Disease Network
Completed	`NCT03449628` - L. Casei DG® in Patients With Irritable Bowel Syndrome.	N/A
Recruiting	`NCT06215222` - Capsule Microbiota Sampling in IBS/Functional Gastrointestinal Disease
Completed	`NCT05016596` - Postprandial Lipids in IBS and Nutritional Treatment	N/A
Recruiting	`NCT04760353` - The Effect of a Probiotic Mixture in Obese Patients With Irritable Bowel Syndrome	N/A
Completed	`NCT06426745` - Split-dose Versus Single-dose Bowel Preparation for Colonoscopy	N/A
Recruiting	`NCT04217733` - Ethosuximide and Pentoxifylline in the Treatment of Abdominal Pain Related to Irritable Bowel Syndrome	Phase 3
Completed	`NCT03178877` - The Prevalence of Irritable Bowel Syndrome Using Rome IV Criteria in Medical Student and The Related Factors	N/A
Recruiting	`NCT05990764` - Effects of a Combination of Polyphenol-rich Extracts, Prebiotics, and Hydrolyzed Fiber on the Quality of Life of Patients With Irritable Bowel Syndrome (IBS)	N/A
Completed	`NCT03948854` - Implementing a Low FODMAP Diet in Irritable Bowel Syndrome Patients	N/A
Completed	`NCT04898257` - Effect of Lactibiane Tolerance® to Treat Leaky Gut in Irritable Bowel Syndrome With Predominant Diarrhea (IBS-D)Patients	N/A