Clinical Trials Logo
  1. Home
  2. Hypoxia
  3. NCT05256069
  4. Details
NCT05256069 Clinical Trial

Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia

Hypoxia Clinical Trial

Official title:
Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05256069
Other study ID # 2087402
Secondary ID
Status Recruiting
Phase Early Phase 1
First received
Last updated
Start date April 26, 2023
Est. completion date July 2024

Study information
Verified date May 2024
Source University of Missouri-Columbia
Contact Jacqueline K Limberg, Ph.D.
Phone 5738822455
Email limbergj@missouri.edu
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The purpose of this project is to identify sex-related differences in the effect of hypoxia on sympathetic vascular transduction.

Recruitment information / eligibility
Status Recruiting
Enrollment 35
Est. completion date July 2024
Est. primary completion date July 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 45 Years
Eligibility Inclusion Criteria: - healthy adult men and women; - 18-45 years of age; - BMI 18-30 kg/m2; - non-pregnant/non-breastfeeding; - non-nicotine users; Exclusion Criteria: - Pregnancy, breastfeeding, hormonal contraceptives - Diagnosed sleep apnea - Current smoking/Nicotine use/drug use - Nerve/neurologic disease - Cardiovascular, hepatic, renal, respiratory disease - Blood pressure =140/90 mmHg - Diabetes, Polycystic ovarian syndrome - Communication barriers - Prescription medications - Recent COVID-19 diagnosis with symptoms

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Propranolol Pill
Participants will receive a ß-blockade (propranolol pill, 1 mg/kg dosed based on participant weight).
• Placebo
Participants will receive a placebo in pill form.

Locations
Country Name City State
United States University of Missouri-Columbia Columbia Missouri

Sponsors (2)
Lead Sponsor Collaborator
University of Missouri-Columbia American Heart Association

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Forearm Blood Flow Measured with venous occlusion plethysmography (mL/dL/min) Change from baseline to 5 minutes
See also
  Status Clinical Trial Phase
Recruiting NCT04498598 - Structural Modification In Supraglottic Airway Device N/A
Completed NCT05532670 - N600X Low Saturation Accuracy Validation
Enrolling by invitation NCT04106401 - Intravascular Volumes in Hypoxia During Antarctic Confinement N/A
Recruiting NCT05883137 - High-flow Nasal Oxygenation for Apnoeic Oxygenation During Intubation of the Critically Ill
Not yet recruiting NCT05817448 - Hypoxia-induced Autophagy in the Pathogenesis of MAP
Recruiting NCT02661152 - DAHANCA 30: A Randomized Non-inferiority Trial of Hypoxia-profile Guided Hypoxic Modification of Radiotherapy of HNSCC. Phase 3
Terminated NCT02801162 - Evaluation of Accuracy and Precision of a New Arterial Blood Gas Analysis System Blood in Comparison With the Reference Standard N/A
Not yet recruiting NCT02201875 - Intrinsic Periodic Pattern of Breathing N/A
Completed NCT02943863 - Regional Ventilation During High Flow Nasal Cannula and Conventional Nasal Cannula in Patients With Hypoxia N/A
Completed NCT01922401 - Inverse Ratio Ventilation on Bariatric Operation N/A
Completed NCT02105298 - Effect of Volume and Type of Fluid on Postoperative Incidence of Respiratory Complications and Outcome (CRC-Study) N/A
Active, not recruiting NCT01681238 - Goal-directed Therapy in High-risk Surgery N/A
Completed NCT01463527 - Using Capnography to Reduce Hypoxia During Pediatric Sedation N/A
Completed NCT01507623 - Value of Capnography During Nurse Administered Propofol Sedation (NAPS) N/A
Withdrawn NCT00638040 - The Gene Expression Studies of the Role of Tumor Microenvironments in Tumor Progression N/A
Active, not recruiting NCT06097754 - Intermittent Exogenous Ketosis (IEK) at High Altitude N/A
Completed NCT04589923 - The VISION-Acute Study
Completed NCT05044585 - Evaluation of RDS MultiSense® in Desaturation Analysis in Healthy Volunteers N/A
Completed NCT03659513 - The Effect of ECMO on the Pharmacokinetics of the Drugs and Their Clinical Efficacy
Completed NCT03221387 - Sleep and Daytime Use of Humidified Nasal High-flow Oxygen in COPD Outpatients N/A