Transauricular Vagus Nerve Stimulation in Children

Status Enrolling by invitation

Clinical Trial Summary

The goal of this clinical trial is to learn about brain waves during transauricular vagus nerve stimulation (taVNS) in healthy children. The main questions it aims to answer are: - What is the safety, tolerability, and physiological response of taVNS in children? - Does the electroencephalogram (EEG) change during taVNS? Participants will - undergo a brief titration session where taVNS will be titrated to below perceptual threshold - receive one session of 30 minutes of taVNS - undergo clinical EEG monitoring during taVNS - Continuous cardiorespiratory monitoring via pulse oximetry and blood pressure every 5 minutes - Answer tolerability questions before, during and after 30 minute taVNS session

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06168071
Study type	Interventional
Source	Washington University School of Medicine
Contact
Status	Enrolling by invitation
Phase	N/A
Start date	November 15, 2023
Completion date	November 15, 2025

View Details

See also
Status	Clinical Trial	Phase
Terminated	`NCT01192776` - Optimizing (Longer, Deeper) Cooling for Neonatal Hypoxic-Ischemic Encephalopathy(HIE)	N/A
Completed	`NCT01092637` - The TOBY Children Study	N/A
Completed	`NCT00006516` - Home Stimulation for Brain-Asphyxiated Infants	Phase 2
Recruiting	`NCT05390060` - Delineating Between Pathophysiologic Phenotypes of Hypoxic Ischemic Brain Injury After Cardiac Arrest	N/A
Completed	`NCT02605733` - The Neu-Prem Trial: Neuromonitoring of Preterm Newborn Brain During Birth Resuscitation
Completed	`NCT00375908` - Umbilical Cord Blood Proteomic Analysis and Neonatal Brain Injury	N/A
Completed	`NCT00005772` - Whole-Body Cooling for Birth Asphyxia in Term Infants	Phase 3
Completed	`NCT02991976` - Oxygen Concentration and Recovery After Carotid Endarterectomy	N/A
Recruiting	`NCT06081283` - Antiseizure Medication in Seizure Networks at Early Acute Brain Injury	Phase 4
Completed	`NCT03112486` - Out-of-hospital Cardiac Arrest (OHCA) Biomarkers
Completed	`NCT01793129` - Preemie Hypothermia for Neonatal Encephalopathy	N/A
Recruiting	`NCT04217551` - Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients	N/A
Completed	`NCT04261335` - The Clinical Trial of CL2020 Cells for Neonatal Hypoxic Ischemic Encephalopathy	Phase 1
Not yet recruiting	`NCT05514665` - Functional Imaging of Baby Brains
Recruiting	`NCT06048796` - Early Cessation of Sedation and TTM in Patients With a Favourable EEG After Cardiac Arrest	N/A
Completed	`NCT03543371` - Neuropsychological Outcome After Cardiac Arrest
Not yet recruiting	`NCT06139250` - Development of a High-speed Multimodal Photoacoustic/Ultrasound System for Functional Imaging of the Neonatal Brain
Recruiting	`NCT04198792` - Predictors for Survival and Good Neurological Outcome in E-CPR and Non CPR Treated Patients
Completed	`NCT01483495` - Assessing Cerebrovascular Reactivity Based on Cerebral Oximetry: a Pilot Study
Completed	`NCT03941015` - Tissue Oxygenation During Treatment of Infant Congenital Heart Defects