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The Effect of Hypovitaminosis D and Vitamin D Supplementation on Fracture Nonunion Rates — VitD  

Hypovitaminosis D Clinical Trial

Official title:
The Effect of Hypovitaminosis D and Vitamin D Supplementation on Fracture Nonunion Rates

Clinical Trial Summary

The purpose of the study is to determine whether vitamin D supplementation in patients with hypovitaminosis D can decrease nonunion (failure to heal) incidence in patients with fractures of the humerus, femur, or tibia. The central hypothesis of the study is that vitamin D supplementation in patients with fractures and hypovitaminosis D will decrease the risk of nonunion compared to placebo treatment.

Clinical Trial Description

Vitamin D plays an important role in maintaining calcium and phosphate balance in the body and is important for maintenance of bone formation, remodeling, and healing. An extensive literature search indicates that although there is evidence that vitamin D deficiency is associated with fracture risk, there is no evidence of the role of vitamin D deficiency in subsequent failure to heal. The aims of study were to: 1) quantify the rate of hypovitaminosis D in an orthopedic trauma population in the Southeastern United States; 2) determine the rate of nonunion in vitamin D deficient patients, and 3) assess the feasibility of acute high-dose vitamin-D supplementation in hypovitaminosis D patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01691833
Study type Interventional
Source Wake Forest University Health Sciences
Contact
Status Completed
Phase N/A
Start date February 2011
Completion date December 2017
View Details
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