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Hypothyroxinemia clinical trials

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NCT ID: NCT01306227 Completed - Hypothyroxinemia Clinical Trials

L-Thyroxine Supplementation for Preterm Newborns Less Than 32 Weeks of Gestation With Hypothyroxinemia

Start date: September 1, 2006
Phase: Phase 3
Study type: Interventional

Transient hypothyroxinemia of prematurity (THOP) is associated with neurodevelopmental impairment in preterm newborns < 32 weeks of gestation (WG). It is not known whether L-Thyroxine supplementation for preterm newborns <32 WG with THOP is beneficial. The purpose of this study is to compare L-thyroxine treatment vs. placebo in newborn less than 32 WG with THOP. The primary endpoint is the neurodevelopmental outcome at two years of life, assessed by the Brunet-Lézine score. The secondary endpoints are: death, bronchopulmonary dysplasia (oxygen therapy at 28 days of life and at 36 weeks of postnatal age), patent ductus arteriosus, shock requiring fluid loading or vasoactive treatments, enterocolitis, intraventricular hemorrhage, retinopathy of prematurity, deafness.

NCT ID: NCT00565890 Completed - Hypothyroxinemia Clinical Trials

Supplemental Thyroxine Treatment for Preterm Infants With Hypothyroxinemia

Start date: December 2005
Phase: N/A
Study type: Interventional

In order to determine the efficacy and safety of thyroxine replacement, a randomized clinical trial of thyroxine supplementation for VLBW infant with hypothyroxinemia during the first month of age is conducted.

NCT ID: NCT00388297 Completed - Pregnancy Clinical Trials

Thyroid Therapy for Mild Thyroid Deficiency in Pregnancy

TSH
Start date: October 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to determine whether treating women, who are diagnosed with a mild imbalance of thyroid hormones during pregnancy, with thyroid hormone replacement affects their children's intellectual development at 5 years of age.