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Dosing of LT4 in Older Individuals — DOT4  

Hypothyroidism Clinical Trial

Official title:
Levothyroxine Dosing in Older Individuals

Clinical Trial Summary

Our overall goal is to determine the clinical consequences of allowing greater flexibility in LT4 dosing in older individuals who take LT4.

Clinical Trial Description

Investigators will perform a randomized, parallel, double-blind clinical trial of two 6-month dosing strategies of levothyroxine (LT4) in patients aged 65 years and older who are already taking a stable dose of at least 1.2 mcg/kg/day of LT4 therapy, one to maintain a target thyroid stimulating hormone (TSH) level of 0.5-2.0 mU/L (lower TSH group) and another of a lower levothyroxine dose to achieve a target TSH of 5.5-7.0 mU/L (higher TSH group). Investigators will assess the effects of levothyroxine therapy at two different TSH targets on symptoms of hypothyroidism, mood, sleep, measures of memory and executive function, weight, lipids, and a marker of bone turnover. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06073665
Study type Interventional
Source University of Pennsylvania
Contact Anne R. Cappola, M.D., Sc.M.
Phone 215-573-5359
Email acappola@pennmedicine.upenn.edu
Status Recruiting
Phase Phase 4
Start date January 31, 2024
Completion date April 1, 2028
View Details
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