Hypothyroidism in Diabetes Clinical Trial
Official title:
Hypothyroidism in Patients With Type 2 Diabetes With Early Diabetic Nephropathy
Diabetes Mellitus is the most common disorder seen. The impact of this disease on the
quality of life, and on morbidity and mortality through the complications that affect the
small and large vessels resulting in retinopathy, nephropathy, neuropathy, and ischemic
heart disease has been emphasized by the findings of the national commission (USA) on
diabetes .
So, there was curiosity to understand and learn the association of this disorder with
another common endocrine gland function that is thyroid gland . The association between
these two disorders has long been recognized although the prevalence of thyroid dysfunction
in diabetic population varies widely between studies. With insulin and thyroid hormone being
intimately involved in cellular metabolism and thus excess or deficit of these hormones
result in functional derangement of the other.
Diabetic patients have higher prevalence of thyroid disorder when compared with the normal
population. Diabetic women are more frequently affected than men and hypothyroidism is more
common than thyrotoxicosis .
Sub-clinical hypothyroidism is an independent risk factor for development of diabetic
nephropathy. Severe hypothyroidism (biochemically) may be completely asymptomatic. Though
our patient had throid stimulating hormone level more than 100 mIU/L, he did not have any
symptoms of hypothyroidism.so diagnosis of hypothyroidism depends on laboratory parameters
rather than clinical findings Recognition and treatment of hypothyroidism in diabetic
patients will benefit glycemic control and improve general well-being ). Diabetic
nephropathy, a major micro-vascular complication of type 2 diabetes mellitus, is an
important cause of chronic kidney disease. It results from interactions between hemodynamic
and metabolic factors .
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