Hypotension Clinical Trial
Official title:
Iinterest of Intravenous Ondansetron in the Prevention of Spinal Anaesthesia-induced Hypotension in Caesarean Section: Double-blind Randomized Controlled Single-centre Study
The intravenous injection of 8mg of ondansetron (a serotonin type 3 receptor antagonist)
before spinal anaesthesia for caesarean section, leads to a smaller reduction in systolic
arterial pressure (SAP).
The expected results are a decrease in the frequency and severity of hypotension, thus
leading to improved comfort for the mother and decreased maternal and foetal morbidity.
Indeed, episodes of hypotension are responsible for impaired foeto-placental circulation,
with sometimes severe consequences for neonates.
It has been established that episodes of hypotension alter foetal pH. Investigators
therefore hope to see a smaller reduction in SAP in the ondansetron group, and show a
benefit for the infant.
One of the objectives of this study is also to observe a decrease in the quantity of
vasopressors used and thus to avoid the adverse effects of their use in high doses.
The expected results are thus an improvement in haemodynamic stability during spinal
anaesthesia for caesarean section.
The originality of this project lies in the use of a CNAP monitor (Continuous Non-invasive
Arterial Pressure) as the collection of haemodynamic data will allow greater precision with
the continuous measurement of AP, as well as a study of maternal cardiac output.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention
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