Hypotension,Controlled Clinical Trial
Official title:
Correlation Analysis of the Effects of Management Pressure Goals (Controlled Hypotension) and Control Volume Goals (Cardiac Output, Stroke Volume Variability, Central Venous Pressure) on Intraoperative Blood and Visual Field Quality
The investigators study 160 patients undergoing spinal surgery.Participants will be randomly divided into study group and control group.The study group will receive controlled hypotension by nitroglycerin and be divided into 3 groups according to CI.
This study will be done in Guangzhou Red Cross Hospital .The investigators study 160 patients
aged from 45 to 70 years,weight from 48 to 68kg classified as American Society of
Anesthesiologists (ASAs) physical status Ⅰ-Ⅱ who will be candidate for posterior
decompression of vertebral canal,discectomy and internal fixation by pediclescrew(one
centrum).The investigators excluded patients with cardiovascular and cerebrovascular
diseases,hepatic or renal dysfunction,and patients receiving drugs that interfere with
coagulation before surgery.
Patients randomly divided into study group(group H,n=120)and control group (group C,n=40).The
study group according to CI(Cardiac Index) levels of intraoperative hypotension period(mean
of CI at T2,T3,T4) were divided into three groups: 1st group: CI: 1.5-2.0 L /(min•m2), 2nd
group: CI: 2.0-3.0 L /(min•m2), 3rd group: CI: 3.0-4.0 L /(min•m2),and which CI < 1.5 or CI >
4.0 was eliminated the experimental group, which, in control group, CI< 2.5 or CI >4.0 was
eliminated the experimental group.
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