Clinical Trials Logo

Clinical Trial Summary

This study will be collecting data on participants undergoing lower body negative pressure (LBNP) to simulate progressive blood loss. The goal of the study is to collect data to allow for development of an algorithm with machine learning to predict blood pressure responses to hyporvolemia by analyzing the arterial waveforms collected during LBNP.


Clinical Trial Description

Death from exsanguination continues to be a major problem in combat casualty care and the care of civilians subjected to trauma. The ability to detect significant blood loss using traditional vital signs (heart rate, blood pressure) is marginal due to a variety of compensatory mechanisms that maintain blood pressure in the face of marked reductions in circulating blood volume. Along these lines, it is critical to develop monitoring devices and algorithms to non-invasively assess central blood volume in humans for the purposes of facilitating more timely interventions. The standard way to simulate hemorrhage in humans is to use Lower Body Negative Pressure (LBNP). In this technique, the lower body of a supine volunteer is enclosed in an airtight container while suction is applied to cause venous pooling in the legs and reduce central blood volume. This technique generates many physiological adaptations that are similar to that observed during blood loss studies in animals and human volunteers. Thus, the purpose of this study is to obtain data for use in developing monitoring technology to detect hemorrhage and other surrogate markers of central blood volume in humans. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03927066
Study type Interventional
Source Mayo Clinic
Contact
Status Completed
Phase N/A
Start date May 12, 2021
Completion date November 8, 2022

See also
  Status Clinical Trial Phase
Recruiting NCT02782819 - A Comparison of Crystalloid Alone Versus Crystalloid Plus Colloid in Shock Resuscitation N/A
Completed NCT06121115 - Norepinephrine Administration Through a Midline Catheter in an Intermediate Care Unit
Terminated NCT04538079 - Non-invasive Objective Assessment of Hemodynamics in Preterm Neonates
Completed NCT03701646 - ClearSight Validation in Pediatrics
Completed NCT02070276 - Predict Fluid Responsiveness in Spinal Anesthesia N/A
Completed NCT04891380 - BCG Biosensor and Non- and Invasive Monitoring During Emergency Medicine Cases, a Prospective Feasibility Study N/A
Recruiting NCT04760977 - Prehospital Management of Hypotensive Trauma in HEMS
Completed NCT03582501 - Measurement of Hemodynamic Responses to Lower Body Negative Pressure N/A
Terminated NCT03407287 - Peripheral Venous Analysis (PIVA) for Predicting Volume Responsiveness and Fluid Status
Active, not recruiting NCT04688450 - BP Management System User Acceptance Testing N/A
Terminated NCT03214809 - The Use of a Point-of-care Thoracic Ultrasound Protocol for Hospital Medical Emergency Teams N/A
Not yet recruiting NCT03671070 - Role of Low Dose Epinephrine Boluses In Acute Hypotension N/A
Completed NCT04497155 - Prehospital Norepinephrine and Early Mortality in Traumatic Shock
Completed NCT04269382 - Accuracy of Non-Invasive Blood Pressure Measurements at the Arm, Calf , and Finger N/A
Recruiting NCT05931601 - Early Initiated Vasopressor Therapy in the Emergency Department Phase 3
Recruiting NCT05355974 - Using Vasopressor Medication to Support Blood Pressure During Intubation Procedure Phase 3
Completed NCT04529005 - Angiotensin II in the Perioperative Management of Hypotension in Kidney Transplant Recipients Phase 4