Hypopituitarism Clinical Trial
Official title:
Effects of CRH on the Sleep in Patients With Hypopituitarism
In contrast to healthy subjects, patients with hypopituitarism do not exhibit endocrine
responses when hormones are injected. This is at least true for those with a complete
insufficiency of the anterior pituitary. For example, administration of corticotropin
releasing hormone (CRH) is not followed by an increase of ACTH and cortisol. Therefore,
"pure" hormone effects can be investigated.
It is well established that hormones of the hypothalamic-pituitary-adrenal axis are involved
in sleep regulation. In rodents, CRH decreased slow wave sleep (SWS). In humans, CRH was
reported to increase wakefulness and to decrease SWS and REM sleep. Primary objective was
therefore to study the effect of CRH on patients with hypopituitarism.
To date, there is no information on sleep of patients with hypopituitarism. Secondary
objective is therefore to compare sleep of patients with hypopituitarism with sleep of
age-matched healthy controls.
n/a
Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science
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