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Hypofibrinogenemia clinical trials

View clinical trials related to Hypofibrinogenemia.

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NCT ID: NCT05711524 Recruiting - Bleeding Clinical Trials

Transfusion of Pathogen Reduced Cryoprecipitated Fibrinogen to Expedite Product Availability in Perioperative Bleeding

Start date: April 1, 2023
Phase: Phase 4
Study type: Interventional

The goal of this quality improvement study is to compare pathogen-reduced cryoprecipitate with traditional cryoprecipitate in liver transplant and cardiovascular patients. The investigators hypothesize that by having immediate access to a readily available thawed blood product that replaces fibrinogen (the main substrate of a blood clot), early bleeding can be treated before it escalates into uncontrolled hemorrhage, and therefore additional blood products, like platelets, plasma and red blood cells can be avoided. Participants will be given one of the two FDA-approved blood products.

NCT ID: NCT05634005 Recruiting - Anemia Clinical Trials

Clinical Decision Support for Blood Transfusions to Improve Guideline Adherence

Start date: February 1, 2023
Phase: N/A
Study type: Interventional

Determine whether clinical decision support (best practice advisory) improves provider adherence to transfusion guidelines for all four major blood components (red blood cells, plasma, platelets, and cryoprecipitate) using a randomized study design to reduce risk of bias. Alerts will be visible to the experimental ordering provider group, while they will not be visible to the control. Both groups still have access to information about best practices: local clinical transfusion guidelines are available and education on blood transfusion best practices will continue regardless of randomization assignment.

NCT ID: NCT03884725 Recruiting - Clinical trials for Blood Coagulation Disorders

Fibrinogen Concentrate In Children Cardiac Surgery 2

FiCCS2
Start date: March 1, 2019
Phase: Phase 4
Study type: Interventional

The purporse of this study is evaluate whether fibrinogen concentrate reduces postoperative bleeding in pediatric cardiac surgery with cardiopulmonary by-pass.