Hyperventilation Clinical Trial
— HVMASKEOfficial title:
CO2 Rebreathing by a Partial Rebreathing Mask as a Treatment of Chronic Idiopathic Hyperventilation - a Pilot Study
Verified date | May 2016 |
Source | University of Aarhus |
Contact | n/a |
Is FDA regulated | No |
Health authority | Denmark: Danish Medicines Agency |
Study type | Interventional |
Background: Chronic Idiopathic Hyperventilation (CIH) is a form of dysfunctional breathing
which has proven hard to treat effectively. The investigators hypothesised that by
periodically inducing normocapnia over several weeks, it would be possible to raise the
normal resting level/set point of CO2 and achieve a reduction of symptoms.
Methods: Six CIH patients were treated two hours a day for four weeks with a novel breathing
mask. The mask was used to induce normocapnia in these chronically hypocapnic patients.
Capillary blood gases (PcCO2, pH, Standard Base Excess (SBE) etc.) were measured at baseline
and once each week at least three hours after mask use, as well as spirometric values,
breath holding tolerance and hyperventilation symptoms as per the Nijmegen Questionnaire
(NQ),.
Status | Completed |
Enrollment | 6 |
Est. completion date | June 2011 |
Est. primary completion date | June 2011 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 70 Years |
Eligibility |
Inclusion Criteria: Chronic idiopathic hyperventilation, i.e.: - PCO2 level below 4.7 kPa AND - SBE value more negative than -1.0 Exclusion Criteria: - Oxygen saturation of 95% or lower at rest |
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Denmark | Aarhus University Hospital | Aarhus |
Lead Sponsor | Collaborator |
---|---|
University of Aarhus | Balancair ApS |
Denmark,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Blood gas and acid/base status | pH, PCO2, PO2, Standard Base Excess | Once every week in the treatment period of four weeks | No |
Secondary | Hyperventilation symptoms | Nijmegen Questionnaire | once a week | No |
Secondary | Breath Hold Tolerance | once a week | No | |
Secondary | Spirometric values | FEV1, FVC | once a week | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05923840 -
Chemoreflex and Baroreflex Alterations Causing Postural Tachycardia Syndrome With Orthostatic Hyperpnea and Hypocapnia
|
N/A | |
Completed |
NCT05488301 -
Effects of Chest Physiotherapy in Hyperventilation Syndrome
|
||
Not yet recruiting |
NCT05222711 -
The Use of a Monitoring Device by General Practitioners During Out-of-hours Care
|
N/A | |
Completed |
NCT03822026 -
Hyperventilation in Patients With Traumatic Brain Injury
|
N/A | |
Recruiting |
NCT05846425 -
Investigating the Effect of Yoga-based Breathing Styles on the Human Brain, With a Focus on Memory
|
N/A | |
Recruiting |
NCT04940273 -
Drug Intervention of Spontaneous Hyperventilation in Patients With Aneurysmal Subarachnoid Hemorrhage
|
N/A | |
Recruiting |
NCT04974060 -
Treatment of Spontaneous Hyperventilation With Remifentanil in Traumatic Brain Injury Patients
|
N/A | |
Recruiting |
NCT05565430 -
Vocal Cord Responses During Hyperventilation in Normal Individuals and in Mild and Severe Asthmatics.
|
||
Active, not recruiting |
NCT00895219 -
Physiotherapy and Dysfunctional Breathing
|
Phase 3 | |
Recruiting |
NCT03384849 -
Evaluation of an MRI-compatible Vital Signs Sensor System
|
N/A | |
Completed |
NCT04232059 -
The Effect of Different Ventilation Strategies on Cerebral Oxygenation Using Near Infrared Spectroscopy (NIRS) in Pediatrics Undergoing Posterior Fossa Tumor Surgery
|
N/A | |
Completed |
NCT03614806 -
Comparison of Transcutaneous Vs End-tidal CO2 Pressure Measurements in Hyperventilation Syndrome Diagnosis
|
N/A | |
Completed |
NCT02743299 -
Investigation of a Novel Turbine-driven Ventilator for Use in Cardiopulmonary Resuscitation
|
Phase 0 | |
Completed |
NCT03240497 -
Effects of Cold Exposure and Breathing Techniques on Immune Response
|
N/A |