Antioxidant Vitaminas and Hypertrophy Adaptations to Resistance Training

Hypertrophy Clinical Trial

Official title:

Vitamins C and Vitamin E and Hypertrophy Adaptations to Resistance Traini

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04828642
• Other study ID #: CIPI/20/209
• Status: Completed
• Phase: N/A
• Start date: February 1, 2021
• Est. completion date: June 30, 2021

Study information

• Verified date: August 2021
• Source: Universidad Europea de Madrid
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This investigations aims to investigate whether supplementation with antioxidant vitamins (vitamin C and vitamin E) can influence, enhancing or blocking, the hypertrophic adaptations caused by strength training in sedentary subjects.

Description:

A randomized, double-blind, placebo-control controlled trial will be conducted. In a previous session volunteers will be interviewed to determine if they meet the inclusion criteria. Will be done two weeks of flushing out other types of supplementation and strenuous physical exercise, along with familiarization with the strength training program and performance tests to be carried out during the rehearsal. Subsequently, it will be a week without exercising to start with the experimental designs. From the start of the trial, participants should avoid physical exercise. strenuous outside the training protocol and if usual, they will only be able to perform one resistance training session per week. Participants should avoid ingesting of foods that contain high amounts of antioxidant compounds: more than two juices of fruits, more than four cups of coffee or tea. Juices with high antioxidant content should be avoided. Alcoholic beverages should also be avoided.

• Group 1 (G1): Antioxidant vitamins (VitC (1000 mg) + VitE (235 mg)) + exercise

• Group 2 (G2): Placebo + exercise A supplementation period of 12 weeks will be carried out. In each period, supplementation with antioxidant vitamins: VitC (1000 mg) + VitE (235 mg) or with placebo.

All participants will ingest the supplementation between 1-3 hours before training, the days of rest in the mornings.

All participants will perform a 12-week strength training protocol. The training session performed in the sharp design will be the first training session in chronic design. Being the baseline (E0) and post-exercise (E1) assessment performed in G1, G2 and G3 also the first evaluation corresponding to the chronic design.

In the middle of the supplementation period (week 6) and at the end, two new evaluations (week 12). Baseline evaluations will be performed prior to an exercise session of week 6 (E2) and at the last exercise session (E3) of the following parameters: performance physique, body composition, micronutrient analysis, muscle ultrasound. I also know conduct post-exercise physical performance assessments Figure 2.

The strength training protocol will be carried out 4 days a week at the facilities sports of the European University. The sessions will be planned by a professional from the Sciences of Physical Activity and Sports. Sessions will be tracked through a diary.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: June 30, 2021
• Est. primary completion date: April 15, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• Experience in strength training of at least one year

Exclusion Criteria:

• Smokers

• Antioxidant supplementation

• Injuries or diseases

Related Conditions & MeSH terms

• Hypertrophy

Intervention

Dietary Supplement:
• Vitamin C and vitamin E
1000 mg 235 mg
• Placebo
Placebo

Locations

Country	Name	City	State
Spain	Universidad Europea de Madrid	Madrid

Sponsors (1)

Lead Sponsor	Collaborator
Universidad Europea de Madrid

Country where clinical trial is conducted

Spain, 

References & Publications (2)

Dutra MT, Alex S, Mota MR, Sales NB, Brown LE, Bottaro M. Effect of strength training combined with antioxidant supplementation on muscular performance. Appl Physiol Nutr Metab. 2018 Aug;43(8):775-781. doi: 10.1139/apnm-2017-0866. Epub 2018 Jun 25. — View Citation

Dutra MT, Martins WR, Ribeiro ALA, Bottaro M. The Effects of Strength Training Combined with Vitamin C and E Supplementation on Skeletal Muscle Mass and Strength: A Systematic Review and Meta-Analysis. J Sports Med (Hindawi Publ Corp). 2020 Jan 8;2020:3505209. doi: 10.1155/2020/3505209. eCollection 2020. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	DEXA	Evaluation of muscle mass with dual energy X-ray absorptiometry	Week 0
Primary	DEXA	Evaluation of muscle mass with dual energy X-ray absorptiometry	Week 10
Primary	Anthropometry	Evaluation of muscle mass by a ISAK 1 level anthropometrist	Week 0
Primary	Anthropometry	Evaluation of muscle mass by a ISAK 1 level anthropometrist	Week 5
Primary	Anthropometry	Evaluation of muscle mass by a ISAK 1 level anthropometrist	Week 10
Primary	Bioimpedance	Evaluation of muscle mass with an Inbody	Week 0
Primary	Bioimpedance	Evaluation of muscle mass with an Inbody	Week 5
Primary	Bioimpedance	Evaluation of muscle mass with an Inbody	Week10
Primary	DOMS	Delayed onset muscle soreness evaluated with visual analoguic scale (0 no pain- 10 maximal pain)	Week 0
Primary	DOMS	Delayed onset muscle soreness evaluated with visual analoguic scale (0 no pain- 10 maximal pain)	Week 5
Primary	DOMS	Delayed onset muscle soreness evaluated with visual analoguic scale (0 no pain- 10 maximal pain)	Week 10
Primary	Manual dinamometry	Handgrip	Week 0
Primary	Manual dinamometry	Handgrip	Week 5
Primary	Leg dinamometry	Dinamometer	Week 0
Primary	Leg dinamometry	Dinamometer	Week 5
Primary	Leg dinamometry	Dinamometer	Week 10
Primary	RPE	10-point scale (no exertion 0- maximal effort 10)	Week 0
Primary	RPE	10-point scale (no exertion 0- maximal effort 10)	Week 5
Primary	RPE	10-point scale (no exertion 0- maximal effort 10)	Week 10
Primary	1 RM	Bench press and squats	Week 0
Primary	1 RM	Bench press and squats	Week 5
Primary	1 RM	Bench press and squats	Week 10
Primary	Parameters determined by ENCODER	Bench press and squats	Week 0
Primary	Parameters determined by ENCODER	Bench press and squats	Week 5
Primary	Parameters determined by ENCODER	Bench press and squats	Week 10