Hypertrophy Clinical Trial
Official title:
The Consumption of Whole Eggs Versus Egg Whites to Stimulate Postprandial Muscle Protein Synthesis
NCT number | NCT03117127 |
Other study ID # | 15693 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | July 2015 |
Est. completion date | May 2017 |
Verified date | April 2018 |
Source | University of Illinois at Urbana-Champaign |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
In crossover trials, ten (N=10) young men (18-35 y) will receive stable isotope tracer infusions and perform a single bout of resistance exercise. Immediately after resistance exercise, participants will ingest stable isotope labeled whole eggs (18 g protein, 17 g fat) or egg whites (18 g protein, 0 g fat) cooked in scrambled form. Repeated blood and muscle biopsies will be collected to determine whole body amino acid kinetics, muscle amino acid transporters, anabolic signaling and myofibrillar protein synthesis rates during the trials.
Status | Completed |
Enrollment | 10 |
Est. completion date | May 2017 |
Est. primary completion date | February 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 35 Years |
Eligibility |
Inclusion Criteria: - Male - Aged 18-35 years - Healthy, active (self-reported to exercise 2 - 4 times per week) - BMI > 18.5 and < 25 kg/m2 Exclusion Criteria: - Smoking - Known allergies to egg consumption - Vegans - Diagnosed GI tract diseases - Arthritic conditions - A history of neuromuscular problems - Diagnosed cognitive impairments - Recent (1 year) participation in amino acid tracer studies - Predisposition to hypertrophic scarring or keloid formation - Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications). - High blood pressure (Systolic > 140 mm HG; Diastolic > 90 mm HG) |
Country | Name | City | State |
---|---|---|---|
United States | Freer Hall | Urbana | Illinois |
Lead Sponsor | Collaborator |
---|---|
University of Illinois at Urbana-Champaign |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Fractional synthetic rate of myofibrillar proteins to whole egg and egg white ingestion | Myofibrillar protein synthesis rates will be assessed during the postabsorptive period for 3 hr and during the 5 hr after the ingestion of the experimental beverages. This will allow us to assess the change from the postabsorptive to the postprandial period | Postabsorptive for 3 hours, Postprandial for 5 hours | |
Secondary | Phosphorylation of muscle anabolic signaling | Phosphorylation of anabolic signaling pathways will be assessed in the fasted state and at 2 and 5 hr after the ingestion of the whole egg and egg whites | Baseline and at 2 and 5 hours after protein ingestion | |
Secondary | Exogenous rate of leucine appearance after ingestion of whole eggs and egg whites. | Dietary derived leucine availability will be measured during the 5 h postprandial phase to compare the dietary-derived leucine availability after whole egg and egg white ingestion. | 5 hour postprandial phase |
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