Hyperthyroidism Clinical Trial
Official title:
Study on the Relationship Between the Thyroid Hormones and the Activity of Brown Adipose Tissue in Human
Brown adipose tissue (BAT) is important in energy expenditure through thermogenesis although the regulatory factors are not well known in humans. There is evidence suggesting that the thyroid hormones affect BAT functions in lower mammals, but the effects of the thyroid hormones on BAT activity in humans are still unclear. The objective of this study was to investigate the effects of thyroid hormones on glucose metabolism of BAT and other organs in humans.
Twenty consecutive patients with Graves'-caused hyperthyroidism who are newly diagnosed and untreated will be studied at the Endocrine Department of Huashan Hospital, Fudan University. All subjects are screened and examined by two senior investigators. Putative BAT activity is determined by the integrated 18F-fluorodeoxyglucose (18F-FDG) PET-CT. After the first PET scan, hyperthyroid patients will be treated with Methimazole following clinical guidelines. None of them uses beta adrenergic blockade. The initial dose of methimazole employed is 10mg thrice a day. During follow-up, the thyroid hormone levels (free triiodothyronine and free thyroxine) will be measured every twenty days. The PET-CT scans and assessments will be repeated when the symptoms have disappeared and the thyroid hormone levels return to normal range. Then the dose of methimazole will be adjusted accordingly. ;
Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05774535 -
Prospective, Observational Study on the Carotid Intima-media Thickness in Patients Undergoing Thyroid Surgery
|
||
| Completed |
NCT02375451 -
Effect of Childhood Radioiodine Therapy on Salivary Function
|
N/A | |
| Recruiting |
NCT00525122 -
Treatment of M.Graves With Radioactive Iodine: Follow-up Study
|
N/A | |
| Completed |
NCT01306916 -
Coexisting Thyroid Disease and Hyperparathyroidism
|
N/A | |
| Completed |
NCT03612908 -
TSHβX1 and D2 THR92ALA in Pregnancy
|
||
| Completed |
NCT03393728 -
Heart Rate Variability and Hyperthyroidism: Evaluation of the Short-term Effects of Propanolol
|
Phase 4 | |
| Completed |
NCT05049551 -
Thyroid Uptake Quantification on a New Generation of Gamma Camera
|
||
| Completed |
NCT02514187 -
A Blinded Study Evaluating the Accuracy and Safety of Cyclotron-produced 99mTc in Adult Patients
|
N/A | |
| Completed |
NCT01727973 -
Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves' Orbitopathy
|
Phase 1/Phase 2 | |
| Completed |
NCT03064542 -
The Role of Thyroid Status in Regulating Brown Adipose Tissue Activity, White Adipose Tissue Partitioning and Resting Energy Expenditure
|
||
| Completed |
NCT03951532 -
Morbidity and Mortality Associated With the Care Journey in Children and Adolescents With Hyperthyroidism
|
||
| Recruiting |
NCT04856488 -
Preoperative Lugol's Solution in Graves' Disease and Toxic Nodular Goiter
|
Phase 3 | |
| Recruiting |
NCT02772705 -
Comparison of SUV Using SPECT/CT Between Grave's Disease Patients and Normal Humans
|
N/A | |
| Active, not recruiting |
NCT02133040 -
Effects of Hyperthyroidism on Amount and Activity of Brown Adipose Tissue
|
||
| Active, not recruiting |
NCT01105923 -
Study of an Intervention to Improve Problem List Accuracy and Use
|
N/A | |
| Recruiting |
NCT03303053 -
Efficacy and Safety of Cholestyramine and Prednisolone as Adjunctive Therapy in Treatment of Overt Hyperthyroidism
|
Phase 3 | |
| Completed |
NCT05385029 -
Fetal and Neonatal Thyroid in Pregnancies With Severe Acute Respiratory Syndrome Coronavirus 2 ( SARS- COV2 ) COVID-19
|
||
| Not yet recruiting |
NCT05252884 -
Calcium+Calcitriol Versus PTH for the Prevention of Hypocalcemia in Thyroidectomy. Randomized Clinical Trial
|
N/A | |
| Completed |
NCT02499471 -
Brown Adipose Tissue Activity and Thyroid Hormone
|
N/A | |
| Completed |
NCT04825964 -
Exercise Capacity, Physical Activity Levels in Patients With Hyperthyroid
|