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Hyperthyroidism clinical trials

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NCT ID: NCT06204393 Recruiting - COVID-19 Clinical Trials

To Investigate the Effect of 2019 Novel Coronavirus Infection on the Condition of Patients With Hyperthyroidism

Start date: January 7, 2023
Phase:
Study type: Observational

The goal of this observational study is to learn about the correlation between COVID-19 and hyperthyroidism in Patients with hyperthyroidism complicated with COVID-19. The main questions it aims to answer are: - Changes of hyperthyroidism in HT patients complicated with COVID-19 - Changes of anxiety and depression in hyperthyroidism patients before and after SARS-CoV-2 infection. Participants will have regular follow-up visits to hyperthyroidism in our hospital, and the investigators will collect the thyroid function and related examination indexes of patients in the corresponding time period.

NCT ID: NCT05828732 Recruiting - Hyperthyroidism Clinical Trials

Clinical Feasibility of Disease Managing Mobile App for Hyperthyroidism

Start date: March 1, 2022
Phase: N/A
Study type: Interventional

This randomized controlled study aims to investigate the effects of using a mobile app that integrates with wearable devices to monitor heart rate, check self-reported symptoms, provide disease-related information, and set medication reminders for patients with thyrotoxicosis. The study intends to evaluate how the use of the app affects disease progression, quality of life, and health-related behaviors associated with the disease.

NCT ID: NCT05774535 Recruiting - Thyroid Cancer Clinical Trials

Prospective, Observational Study on the Carotid Intima-media Thickness in Patients Undergoing Thyroid Surgery

TIROVASC
Start date: September 5, 2022
Phase:
Study type: Observational

The evaluation of carotid intima-media thickness (cIMT) has become a possible predictor of the future risk of cardiovascular diseases (CVD). Evidence to date shows that cIMT augmentation is correlated with the extent of atherosclerosis in the coronary arteries and with other risk factors for CVD. More recently, several studies have evaluated the association of cIMT with stroke, to determine whether this measure can also predict future cardiovascular events. Although the published evidence is scarce and fragmentary, the cIMT retains an increasingly interesting role as a marker of atherosclerotic pathology. The purpose of the study is to analyze cIMT in patients undergoing thyroidectomy to evaluate a possible correlation between the cIMT variation after the procedure and the cause of the thyroid disease, the levels of thyroid hormones, and the lipid or other markers of atherosclerosis levels. The primary endpoint will be the variation of the measure of the cIMT before and after surgery. Secondary endpoints will be: - major cardiovascular adverse events (death, major stroke, minor stroke, transient ischemic attack) in the short-term period (≤30 days after the procedure); - major cardiovascular adverse events (death, major stroke, minor stroke, transient ischemic attack) in the long-term period (>30 days after the procedure); - the technical success of the procedure; - the rate of postoperative complications. To date, there are no data that differentiate patients based on the causes of thyroid disease. The results of the present study will allow for correlating the variation of the cIMT to the causes of thyroid disease, the levels of thyroid hormones, and the levels of lipid and other markers of atherosclerosis. Results from the present study may provide insights into possible areas of quality improvement. It may also influence the economic impact associated with carotid revascularization techniques, in terms of hospital charges and discharges to skilled nursing and rehabilitation facilities.

NCT ID: NCT05599841 Recruiting - Osteoarthritis Clinical Trials

Povidone Iodine Irrıgation at Hip-Knee Arthroplasty

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

Povidone iodine (PI) solution is an antimicrobial solution that can be used at hip and knee arthroplasty cases. It contains iodine that may be absorbed by the body. This study aims to investigate any absorption caused by PI solution.

NCT ID: NCT05142904 Recruiting - Clinical trials for Radiofrequency Ablation

Radiofrequency Ablation Versus I-131 for Solitary Autonomous Thyroid Nodules

RABITO
Start date: November 17, 2021
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare treatment of hyperthyroidism with radiofrequency ablation or I-131 for solitary autonomous thyroid nodules.

NCT ID: NCT04946123 Recruiting - Hyperthyroidism Clinical Trials

Hyperthyroidism: Methimazole Plus L-carnitine and Selenium

Start date: July 5, 2021
Phase: N/A
Study type: Interventional

The study aims to investigate the benefits of methimazole treatment in patients with hyperthyroidism, associated with supplementation of L-carnitine and Selenium.

NCT ID: NCT04879173 Recruiting - Clinical trials for Hyperthyroidism/Thyrotoxicosis

Clinical Value of Microvascular Ultrasonography in Real-time Differential Diagnosis of Thyrotoxic Patients

Start date: October 14, 2020
Phase:
Study type: Observational

This study aims to verify the clinical value of thyroid ultrasound with microvascular flow imaging in thyrotoxic patients for differential diagnosis between hyperthyroidism and thyroiditis. We intend to use the RS85 Ultrasound device manufactured by Samsung Medison. Graves' disease and painless thyroiditis/subacute thyroiditis are the main cause of thyrotoxicosis. Precise discrimination between Graves' disease and painless thyroiditis/subacute thyroiditis is clinically very important in determining treatment methods, such as the prescription of antithyroid drugs. Primary endpoint was to verify the value of vascularity index, defined by Blood pixel in range of image / Total pixel in range of image .Seondary endpoint was to verify the superiority value of Microvascular flow imaging to discriminate thyrotoxicosis patients compared with Color doppler/ Power doppler ultrasound imaging and conventional ultrasound imaging.

NCT ID: NCT04856488 Recruiting - Hyperthyroidism Clinical Trials

Preoperative Lugol's Solution in Graves' Disease and Toxic Nodular Goiter

Start date: November 18, 2021
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess if preoperative treatment with Lugol's solution prior to thyroidectomy can reduce the surgical complications hypoparathyroidism and laryngeal nerve palsy

NCT ID: NCT04776993 Recruiting - Graves' Orbitopathy Clinical Trials

A Conservative vs an Ablative Approach for Treatment of Hyperthyroidism in Patients With Graves' Orbitopathy

ABLAGO
Start date: March 2, 2023
Phase: Phase 3
Study type: Interventional

Graves' disease (GD) is the most frequent cause of hyperthyroidism in iodine sufficient countries and Graves' orbitopathy (GO) is its most common extrathyroidal manifestation. Restoration and maintenance of euthyroidism are imperative in Graves' disease patients with GO. The main treatment options for Graves' hyperthyroidism are antithyroid drugs, radioactive iodine (RAI), and surgery. Whether one or the other therapy for Graves' hyperthyroidism offers the best protection against GO is not established. The study is aimed at comparing the effects of a conservative approach (antithyroid drugs, ATDs, experimental arm) vs an ablative approach (radioiodine or total thyroidectomy) of thyroid treatment on the overall outcome of GO in patients with GD and moderate-to-severe and active GO treated with intravenous glucocorticoids.

NCT ID: NCT03434067 Recruiting - Thyroidectomy Clinical Trials

The Application of Rapid PTH Test Paper in Operation of Hyperparathyroidism

Start date: January 1, 2018
Phase:
Study type: Observational [Patient Registry]

The half-life of the parathyroid hormone is about 4min, blood pth test is use in operation to confirm that parathyroid tumor is removed. but the blood pth test is time consuming and unpractical in most of hospital. this study will compare the application of rapid PTH test paper in operation of hyperparathyroidism.PTH test were measured in operation in different way. it will test at the time of preoperation, 15 minutes after surgery, 1 hour after surgery and 24 hours after surgery. thus evaluate the reliability and accuracy of PTH test paper in evaluating the Miami principles with the linear relation of blood PTH and the PTH test paper method.