Clinical Trial Summary
Hyperthyroidism is an endocrine disease with a high incidence rate, and some patients are
difficult to effectively control the condition after long-term drug treatment, and the
disease recurs, forming refractory hyperthyroidism. The search for a new safe, effective and
minimally invasive treatment has become a research hotspot. Ultrasound-guided radiofrequency
ablation is a hot spot in clinical research due to its advantages of low trauma, high safety,
precise inactivation of lesions, and multiple ablation. However, there is no unified standard
for the number and scope of ablation in the treatment of refractory hyperthyroidism by
radiofrequency ablation, and there is a lack of data on the effectiveness and safety of the
treatment with large samples and long-term effects. Therefore, how to establish a
standardized treatment strategy and appropriate plan for ablation of refractory
hyperthyroidism based on clinical practice is an urgent problem to be solved. The purpose of
this study was to prospectively include refractory hyperthyroidism for ultrasound-guided
radiofrequency ablation, and to evaluate the efficacy and safety of hyperthyroidism ablation
by comparing the changes in symptoms and signs, serology, and imaging of patients before and
after ablation. The relevant factors affecting the efficacy of ablation were analyzed and the
most appropriate ablation scope was determined. Radiofrequency ablation was retrospectively
compared with traditional surgery and 131I treatment, and the near- and medium-term treatment
effects, incidence of adverse reactions and complications, as well as the economic benefits
and sociopsychological differences of the three treatment methods were compared.
The expected outcome of this study is to establish a research cohort of hyperthyroidism
ablation based on a large sample population, and to establish the most appropriate and
effective regimen for radiofrequency ablation of refractory hyperthyroidism compared with
traditional surgery and 131I treatment with safety and near- and medium-term efficacy. The
Department of Ultrasound Medicine of China-Japan Friendship Hospital has accumulated rich
experience in the ablation treatment of benign and malignant thyroid nodules and
hyperthyroidism, and has completed more than 200 cases of thyroid ablation in the past two
years. Under the leadership of Professor Zhang Bo, the research team of this project has
conducted a number of clinical studies on the ultrasound diagnosis and treatment of thyroid
diseases, presided over and participated in more than 20 national, provincial and
university-level scientific research courses, and the first author or corresponding author
wrote more than 70 articles in related fields, which laid a solid research foundation for the
conduct of this study.
