Hypertension Clinical Trial
— INDEBPOfficial title:
In-Hospital Detection of Elevated Blood Pressure (INDEBP): Prevalence of New or Uncontrolled Hypertension and Safety of Postponement of Antihypertensive Treatment Adaption in Medical In-patients
Verified date | November 2023 |
Source | University Hospital, Basel, Switzerland |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The goal of this clinical trial is to analyse the prevalence of new or uncontrolled arterial hypertension (AHT) after hospital discharge of medical in-patients with elevated blood pressure (BP) values during hospitalisation. The main questions it aims to answer are: - Do elevated BP values during hospitalisation correspond to new or uncontrolled AHT after hospital discharge? - Is it safe to postpone adaption of antihypertensive treatment until after proper evaluation of AHT after hospital discharge? Participants will either be treated according to their physicians' decision or antihypertensive treatment adaptions will be postponed until after hospital discharge.
Status | Not yet recruiting |
Enrollment | 800 |
Est. completion date | December 31, 2024 |
Est. primary completion date | December 31, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Patient hospitalized on the internal medicine ward for non-cardiovascular causes, i.e. patients hospitalized for conditions, which are not acutely worsened by uncontrolled AHT - Asymptomatic elevated BP values (defined as 140-180 mmHg systolic and/or 90-110 mmHg diastolic) on at least 2 occasions - Ability to understand study procedures and to provide written informed consent Exclusion Criteria: - Hospitalization for any conditions which can be worsened by uncontrolled AHT: - Cerebrovascular events - Acute coronary syndrome - Acute or decompensated heart failure - Any condition preventing ABPM - Pregnant or lactating women - Failure to provide informed consent |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Annina Vischer |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Prevalence of persisting new or uncontrolled arterial hypertension | Elevated blood pressure values in ambulatory blood pressure monitoring | 4 weeks after hospital discharge | |
Primary | Prevalence of a combined hypertensive complication endpoint | Consisting of intracerebral bleeding, ischemic stroke, myocardial infarction, cardiovascular death or cardiovascular re-hospitalization | Until 4 weeks after hospital discharge | |
Primary | Prevalence of a combined hypotensive complication endpoint | Consisting of falls, acute kidney injury, electrolyte disturbances, re-hospitalizations due to hypotension, or BP values on ABPM below the lower treatment limit | Until 4 weeks after hospital discharge | |
Secondary | Clinic blood pressure measurement in mmHg | Documented in the patient documentation | At baseline | |
Secondary | Research blood pressure measurement in mmHg | Standardized blood pressure measurement taken by research staff | At baseline | |
Secondary | Prevalence of previously unknown arterial hypertension | No previously documented diagnosis of arterial hypertension and no antihypertensive treatment | At baseline | |
Secondary | Prevalence of female gender | As reported by participant | At baseline | |
Secondary | Prevalence of re-hospitalization for any cause | According to hospital documentation and patient interrogation | Until 4 weeks after hospital discharge |
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