Hypertension Clinical Trial
— MOBILE-ICHOfficial title:
MOBILE Health Intervention in IntraCerebral Hemorrhage Survivors
This randomized controlled trial investigates the efficacy and safety of mobile health intervention in managing hypertension after Intracerebral Hemorrhage (ICH).
Status | Recruiting |
Enrollment | 140 |
Est. completion date | March 31, 2026 |
Est. primary completion date | March 31, 2025 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 85 Years |
Eligibility | Inclusion Criteria: - Primary ICH Diagnosis - Age = 18 years - Discharge Modified Rankin Scale of =4 Exclusion Criteria: - Expected life expectancy of <1 year - Patient or caregiver does not have access to WeRISE App. - Patient or caregiver does not know how to use WeRISE App . - Inability to perform home BP monitoring - Inability to participate in follow-up activity - Contraindication for intensive and rapid lowering of blood pressure (Known >70% cerebral vascular stenosis; History of fall, dizziness or syncope due to hypotension; Any other medical condition that is deemed contraindicated for low blood pressure - Bleeding tendency (Platelet count < 75 x 10^9/L; Known coagulation disorder) - Severe renal impairment (Estimated glomerular filtration rate using CKD-EPI formula <30 ml/min/1.73m2) - Severe liver impairment (Child-Pugh C cirrhosis) - Known contraindication or allergy to two or more anti-hypertensive classes |
Country | Name | City | State |
---|---|---|---|
Hong Kong | Queen Mary Hospital | Hong Kong |
Lead Sponsor | Collaborator |
---|---|
The University of Hong Kong |
Hong Kong,
Biffi A, Teo KC, Castello JP, Abramson JR, Leung IYH, Leung WCY, Wang Y, Kourkoulis C, Myserlis EP, Warren AD, Henry J, Chan KH, Cheung RTF, Ho SL, Anderson CD, Gurol ME, Viswanathan A, Greenberg SM, Lau KK, Rosand J. Impact of Uncontrolled Hypertension at 3 Months After Intracerebral Hemorrhage. J Am Heart Assoc. 2021 Jun;10(11):e020392. doi: 10.1161/JAHA.120.020392. Epub 2021 May 15. — View Citation
Teo KC, Keins S, Abramson JR, Leung WCY, Leung IYH, Wong YK, Yeung C, Kourkoulis C, Warren AD, Chan KH, Cheung RTF, Ho SL, Gurol ME, Viswanathan A, Greenberg SM, Anderson CD, Lau KK, Rosand J, Biffi A. Blood Pressure Control Targets and Risk of Cardiovascular and Cerebrovascular Events After Intracerebral Hemorrhage. Stroke. 2023 Jan;54(1):78-86. doi: 10.1161/STROKEAHA.122.039709. Epub 2022 Nov 2. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Rate of controlled hypertension 12 weeks after ICH | Office BP <130/80 mmHg | 12 weeks | |
Secondary | Change of BP from recruitment to 12 weeks | The difference between BP measurement on recruitment and at 12 weeks | 12 weeks | |
Secondary | Rate of controlled hypertension 26 weeks after ICH | Office BP <130/80 mmHg | 26 weeks | |
Secondary | Life Simple 7 Score at 12 and 26 weeks | Score ranging from 0-14 points, with the higher scores indicating better lifestyle health | 12 and 26 weeks |
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