Hypertension Clinical Trial
— CAREOfficial title:
Cardiovascular Adaptations to Resistance Exercise: Effects of Set Configuration on Normotensive and Hypertensive Postmenopausal Women
Verified date | March 2024 |
Source | Universidade da Coruña |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The main purpose of this project is to analyze the effect of set configuration of resistance exercise on cardiovascular responses and adaptations of postmenopausal women. Additionally, since previous studies have shown that individual´s blood pressure level can influence on the impact of resistance training programs on cardiovascular changes, we aim to contrast acute and chronic changes to resistance training programs in normotensive and hypertensive postmenopausal women.
Status | Active, not recruiting |
Enrollment | 40 |
Est. completion date | September 30, 2025 |
Est. primary completion date | April 30, 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 50 Years to 65 Years |
Eligibility | Inclusion Criteria: - Five years since menopause - Physically active (150-300 minutes a week of moderate physical activity or at least 75 minutes a week of vigorous physical activity) - No more than 3 cardiovascular risk factors - Asymptomatic and without cardiovascular (except hypertension), metabolic or renal disease - Hypertensive women should be diagnosed with grade 1 hypertension that must be well controlled by one drug and with low or moderate cardiovascular risk. Exclusion Criteria: - Having grade 2 or 3 hypertension - Participants with hypertension and taking more than one drug for controlling hypertension or by a drug that can interfere cardiovascular responses to exercise - To be or have been receiving hormonal replacement therapy - To show hypertensive response to exercise |
Country | Name | City | State |
---|---|---|---|
Spain | Faculty of Sport Sciences and Physical Education | Bastiagueiro | A Coruña |
Lead Sponsor | Collaborator |
---|---|
Universidade da Coruña | Ministerio de Ciencia e Innovación, Spain |
Spain,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Baroreflex sensitivity | Simultaneous electrocardiogram and beat-to-beat blood pressure recordings obtained by a photoplethysmography sensor will be used for calculating baroreflex sensitivity by sequential methods. Units: mmHg/ms | 25 minutes | |
Primary | Blood pressure | Systolic, diastolic and mean blood pressure will be obtained by a photoplethysmography sensor. Units: mmHg | 25 minutes | |
Primary | Heart rate variability in time domain | Standard deviation of the normal-to-normal interval (SDNN) and root of the mean squared differences of successive NN intervals (RMSSD) will be obtained by analyzing inter-beat intervals from electrocardiogram recordings. Units: ms | 25 minutes | |
Primary | Heart rate variability in frequency domain | Obtained from spectral analysis of electrocardiogram recordings. High (HF) and Low (LF) frequency bands power will be determined by Fast Fourier Transformation method. Units: ms2/Hz | 25 minutes | |
Primary | Blood pressure variability | It will be calculated by spectral analysis of beat-to-beat blood pressure recordings obtained by a photoplethysmography sensor. Units: mmHg2/Hz | 25 minutes | |
Primary | Resting metabolic rate | It will be obtained by measuring oxygen consumption at rest. Units: kcal/·day | 60 minutes | |
Primary | Arterial stiffness | It will be assessed by finger-toe pulse wave velocity method. Units: m/s | 15 minutes | |
Primary | Bone mineral density | It will be obtained by a Ultrasound Bone Densitometer. Units: g/cm | 10 minutes | |
Secondary | Skeletal muscle mass | Estimated by Bioelectrical impedance analysis. Units: kg and percentage of body mass | 10 minutes | |
Secondary | Fat mass | Estimated by Bioelectrical impedance analysis. Units: kg and percentage of body mass | 10 minutes | |
Secondary | Body mass | Measured in kg | 10 minutes | |
Secondary | Body mass index | Measured in kg/m^2 | 2 minutes | |
Secondary | Height | Measured in m | 10 minutes | |
Secondary | Muscle thickness | Measured with an ultrasound device. Units: mm | 20 minutes | |
Secondary | Torque-velocity relationship | Relationship between torque (N/m) and angular velocity (°/s). Obtained by performing maximum torque at specific velocities in an isokinetic dynamometer | 60 minutes | |
Secondary | Power-velocity relationship | Relationship betweenPower (W) and angular velocity (°/s). Obtained by performing maximum torque at specific velocities in an isokinetic dynamometer | 60 minutes | |
Secondary | Maximum isometric torque | Maximum torque recorded at fixed angular position. It will be measured with an isokinetic dynamometer. Units: N/m | 60 minutes | |
Secondary | Lipid profile to determine cardiovascular risk | Total Cholesterol in mg/dL
High-Density Lipoprotein in mg/dL Triglycerides in mg/dL Calculated Low-Density Lipoprotein in mg/dL |
5 minutes |
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