Blood Pressure and Cardiac Autonomic Adaptations to Isometric Exercise Training

Hypertension Clinical Trial

Official title:

Blood Pressure and Cardiac Autonomic Adaptations to Isometric Exercise Training: a Randomised Sham-controlled Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05025202
• Other study ID #: 18/SAS/47C
• Status: Completed
• Phase: N/A
• Start date: January 15, 2019
• Est. completion date: September 11, 2020

Study information

• Verified date: August 2021
• Source: Canterbury Christ Church University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

A randomized, sham-controlled intervention measuring the effects of isometric exercise training (IET) on blood pressure and cardiac autonomics.

IET has been proven effective in a plethora of randomized trials, but very little research has employed a sham-controlled design. This researched involved the recruitment of 30 participants who completed a 4 week IET intervention, sham control of the IET intervention, or a non-intervention control period. Pre and post blood pressure and cardiac autonomic measures were acquired and analysed.

The hypothesis of this trial was a significant effect of IET on blood pressure, with no such effects following the sham control or normal control interventions.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: September 11, 2020
• Est. primary completion date: December 29, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Healthy with no significant health conditions contraindicating exercise

• Over 18 years of age

• Physically inactive

Exclusion Criteria:

• Achieving current physical activity guidelines

• Abnormal resting ECG

• under 18

Related Conditions & MeSH terms

• Hypertension

Intervention

Other:
• Isometric exercise training
A form of exercise involving static contraction against a wall, sustained for 2 minutes x4 sets per session. 3 sessions a week were required. The intensity was designed to achieve 95% of the participants maximum heart rate.

Locations

Country	Name	City	State
United Kingdom	Canterbury Christ Church University	Canterbury	Kent

Sponsors (1)

Lead Sponsor	Collaborator
Canterbury Christ Church University

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Blood pressure (systolic, diastolic and mean BP)	Resting office blood pressure measured at brachial artery	At the start of the intervention (pre 4 week intervention)
Primary	Blood pressure (systolic, diastolic and mean BP)	Resting office blood pressure measured at brachial artery	At the end of the intervention (post 4 weeks)
Primary	Cardiac autonomics measured at HRV	LF and HF power spectral measures	At the start of the intervention (pre 4 week intervention)
Primary	Cardiac autonomics measured at HRV	LF and HF power spectral measures	At the end of the intervention (post 4 weeks)
Secondary	continuous 5-minute blood pressure (systolic, diastolic and mean BP)	5 minute mean of resting blood pressure measured beat-to-beat	At the start of the intervention (pre 4 week intervention)
Secondary	continuous 5-minute blood pressure (systolic, diastolic and mean BP)	5 minute mean of resting blood pressure measured beat-to-beat	At the end of the intervention (post 4 weeks)