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A Study to Evaluate Efficacy and Safety of ALN-AGT01 in Patients With Mild To-Moderate Hypertension — KARDIA-1  

Hypertension Clinical Trial

Official title:
A Randomized, Double-blind, Placebo-Controlled, Dose-Ranging Multicenter Study to Evaluate the Efficacy and Safety of ALN-AGT01 in Patients With Mild-to-Moderate Hypertension

Clinical Trial Summary

The purpose of this study is to evaluate the effect of ALN-AGT01 on systolic and diastolic blood pressure and to characterize the pharmacodynamic (PD) effects and safety of ALN-AGT01.

Clinical Trial Description

Participants will receive ALN-AGT01 or placebo for the first 6 months of the 12-month double-blind (DB) treatment period. Participants randomized to placebo will be re-randomized at Month 6 to 1 of the 4 initial ALN-AGT01 regimens until the end of the 12-month DB treatment period. Participants randomized to ALN-AGT01 regimens will remain on their originally assigned regimens through remainder of the study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04936035
Study type Interventional
Source Alnylam Pharmaceuticals
Contact
Status Active, not recruiting
Phase Phase 2
Start date July 7, 2021
Completion date December 4, 2024
View Details
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