Hypertension Clinical Trial
Official title:
Rationale and Design of a Simple Randomized Trial Evaluating Comparative Effects of Perindopril and Zofenopril in Blacks Hypertensive Patients: Short Term Effects on Cardiac and Oxidative Status With Perindopril or Zofenopril (PEZO-HP) Trial
The aim of the study is to compare the short term effect of perindopril and zofenopril in the
management of hypertension and the oxydative stress in blacks hypertensive patients.
PEZO-HP is a double-arm, double-blind, randomized and parallel clinical trial conducted at
the Yaoundé Central Hospital.
Aim: to determine and compare the short term effect of angiotensin converting in the
management of hypertension as well as the oxidative effect of Zofenopril and perindopril in
blacks hypertensive patients in the Yaoundé Central Hospital.
Method: A double-arm, double-blind, randomized and parallel clinical trial conducted at the
Yaoundé Central Hospital. Hypertensive patients who are not taking angiotensin-converting
enzyme inhibitor or angiotensin receptors blockers, are randomize into 2 groups. Depending on
the group, the intervention consisted of the administration of Perindopril 10 mg daily or
Zofenopril 30 mg daily for 08 weeks. The endpoints were the nycthemeral blood pressure
profile, pro oxidant marker (malondialdehyde) and anti-oxidant marker (Ferric reducing
antioxidant).
Progress: Recruitment for PEZO-HP was completed in May 2019 with 24 patients.
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