Impact of Aerobic Exercise Training on Sympathetic Vasoconstriction and Vascular Function in Essential Hypertension

Hypertension,Essential Clinical Trial

— IMPROVEH  

Official title:

Impact of Aerobic Exercise Training on Sympathetically Mediated Vasoconstriction and Vascular Function in Individuals With Essential Hypertension (IMPROVEH)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03778489
• Other study ID #: PANX-HYP
• Status: Completed
• Phase: N/A
• Start date: February 19, 2019
• Est. completion date: November 1, 2022

Study information

• Verified date: November 2022
• Source: University of Copenhagen
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Sympathetic nervous activity plays an important role in the development of hypertension and studies have shown that the pannexin-1 channel is involved in the signalling of the sympathetic activity to the vascular bed. The main project aim is to investigate the effects of 10 weeks of high intensity training on the effect of the sympathetic nervous activity on vascular function in individuals with essential hypertension. A secondary aim is to assess the role of essential hypertension and physical activity on vascular endothelial function,

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: November 1, 2022
• Est. primary completion date: November 1, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 35 Years to 65 Years

Eligibility

Inclusion Criteria:

• Sedentary men and women age 35 - 65 years

• Resting blood pressure >140/90 mmHg or Resting blood pressure <140/90 mmHg

• Essential hypertension

• Non or exclusively antihypertensive medication

Exclusion Criteria:

• Hypertensive condition other than essential hypertension

• Other chronical diseases

• Smoking

• Excess alcohol intake or drug abuse

Related Conditions & MeSH terms

• Essential Hypertension
• Hypertension
• Hypertension,Essential

Intervention

Other:
• Training
10 weeks of high intensity exercise training. 2-3 trainings per week of approx. 40 min.

Locations

Country	Name	City	State
Denmark	University of Copenhagen	Copenhagen

Sponsors (3)

Lead Sponsor	Collaborator
University of Copenhagen	Danish Council for Independent Research, Lundbeck Foundation

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Blood pressure	Changes in systolic and diastolic blood pressure	Before and after 8 weeks of training
Secondary	Pannexin channel function assessed in vivo	Pannexin channel function is assessed by measurement of vascular conductance with and without channel inhibition	Before and after 8 weeks of training
Secondary	Pannexin channel distribution in skeletal muscle tissue	Pannexin channel distribution is assessed immunohistochemically in muscle samples	Before and after 8 weeks of training
Secondary	Sympathetic activity	Direct measurement of Muscle Sympathetic Nervous Activity via microneurography	Before and after 8 weeks of training
Secondary	Vascular function	Vascular conductance measured by ultrasound doppler during infusion of vasoactive substances	Before and after 8 weeks of training
Secondary	Mitochondrial function in endothelial cells	Endothelial cell mitochondrial respiration is measured by High Resolution Respirometry	Before and after 8 weeks of training
Secondary	Reactive oxygen species formation in in endothelial cells	Endothelial cell production of reactive oxygen species is measured by High Resolution Respirometry	Before and after 8 weeks of training
Secondary	Rheology	Platelet rheology. The viscoelastic measurements are based on attainment of the Gel Point (GP) from which the fractal dimension, df, is determined.	Before and after 8 weeks of training
Secondary	Platelet reactivity	Platelet reactivity is assessed by multiplate aggregometry	Before and after 8 weeks of training
Secondary	Maximal oxygen uptake	Direct Measurement of oxygen uptake during a graded test on cycle ergometer	Before and after 8 weeks of training
Secondary	Body Composition	Measured by Dual energy x-ray absorptiometry	Before and after 8 weeks of training
Secondary	Endothelial cell characterization	Assessment of protein and mRNA-levels of proteins of relevance for endothelial function	Before and after 8 weeks of training
Secondary	Skeletal muscle characterization	Assessment of protein and mRNA-levels of proteins of relevance for skeletal muscle function	Before and after 8 weeks of training