Hypertension Clinical Trial
Official title:
Treatment Adherence and Blood Pressure Outcome Among Hypertensive Out-patients in Two Tertiary Hospitals in Sokoto, Northwestern Nigeria
It is estimated that more than 70% of patients on antihypertensive medications do not take
them as prescribed. Treatment non-adherence practice may be particularly higher in developing
countries where there is poor accessibility to medicines and healthcare services, coupled
with low level of awareness of the lifelong nature of hypertension treatment among patients.
Optimal control of blood pressure has been reported to reduce the incidence of morbidity and
mortality associated with hypertension. Thus, adoption of healthy lifestyle as well as
ensuring regular and continuous adherence to prescribed medications are integral to
successful management of hypertension to achieve the target blood pressure goals.
The present study comprehensively evaluated adherence to pharmacotherapy and
non-pharmacological measures among ambulatory hypertensive patients attending two healthcare
institutions in Sokoto, Northwestern Nigeria. Reasons for treatment non-adherence were
evaluated, while perception and beliefs about hypertension and its management were also
explored, with pharmacist-led patient-specific adherence education provided as appropriate to
resolve the knowledge gap(s). Association between treatment adherence and blood pressure
outcome at contact and the subsequent 2-months clinic appointment were investigated.
Patients aged 18 years and above, with a primary diagnosis of hypertension, and who were on
antihypertensive medications for at least 3-months were recruited from the medical outpatient
clinic of Usmanu Danfodiyo University Teaching Hospital and the Specialist Hospital, both
within Sokoto metropolis, Sokoto state, Northwestern Nigeria. Newly diagnosed patients,
in-patients and those who declined participation were excluded from the study.
Background: Hypertension is a common cardiovascular disease worldwide, contributing 4.5% of
the global disease burden and 12.8% premature deaths annually. Despite recent advances in
drug therapy, majority of diagnosed hypertensive patients are poorly controlled. Reasons for
inadequate control of hypertension are heterogeneous including low adherence to
antihypertensive medications and lifestyle changes, low compliance with scheduled follow-up
visits and suboptimal pharmacotherapy. This study evaluated adherence to pharmacotherapy and
non-pharmacological measures among ambulatory hypertensive patients, reasons for treatment
non-adherence were evaluated, while perception and beliefs about hypertension and its
management were also explored, with pharmacist-led patient-specific adherence education
provided as appropriate to resolve the knowledge gap(s). Association between treatment
adherence and blood pressure outcome at contact and the subsequent 2-months clinic
appointment were investigated.
Method: This study involved a cross-sectional questionnaire-guided interview and
retrospective review of medical records of 605-patients from two hospitals. Nine-item
modified adherence predictor scale was used to assess medication adherence. Overall adherence
score to lifestyle modifications was obtained from the total scores from 4-domains of
non-pharmacological measures including cigarette smoking and alcohol cessation,
salt-restriction and exercise. Patient-specific adherence education was provided at contact
to resolve the knowledge gap(s). Clinical-parameters especially the blood pressure values
were retrieved at contact and subsequent 2-months appointment. Data were summarised using
frequency, percentage, 50th percentile and mean ± standard deviation. Chi-square test was
used to evaluate association between socio-demographic variables and adherence to
antihypertensive medication and lifestyle recommendations. Student's t-test was used to
investigate relationship between treatment adherence and blood pressure outcome at p < 0.05
considered significant.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Terminated |
NCT04591808 -
Efficacy and Safety of Atorvastatin + Perindopril Fixed-Dose Combination S05167 in Adult Patients With Arterial Hypertension and Dyslipidemia
|
Phase 3 | |
Recruiting |
NCT04515303 -
Digital Intervention Participation in DASH
|
||
Completed |
NCT05433233 -
Effects of Lifestyle Walking on Blood Pressure in Older Adults With Hypertension
|
N/A | |
Completed |
NCT05491642 -
A Study in Male and Female Participants (After Menopause) With Mild to Moderate High Blood Pressure to Learn How Safe the Study Treatment BAY3283142 is, How it Affects the Body and How it Moves Into, Through and Out of the Body After Taking Single and Multiple Doses
|
Phase 1 | |
Completed |
NCT03093532 -
A Hypertension Emergency Department Intervention Aimed at Decreasing Disparities
|
N/A | |
Completed |
NCT04507867 -
Effect of a NSS to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III
|
N/A | |
Completed |
NCT05529147 -
The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail Elderly
|
||
Recruiting |
NCT06363097 -
Urinary Uromodulin, Dietary Sodium Intake and Ambulatory Blood Pressure in Patients With Chronic Kidney Disease
|
||
Recruiting |
NCT05976230 -
Special Drug Use Surveillance of Entresto Tablets (Hypertension)
|
||
Completed |
NCT06008015 -
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of "BR1015" and Co-administration of "BR1015-1" and "BR1015-2" Under Fed Conditions in Healthy Volunteers
|
Phase 1 | |
Completed |
NCT05387174 -
Nursing Intervention in Two Risk Factors of the Metabolic Syndrome and Quality of Life in the Climacteric Period
|
N/A | |
Completed |
NCT04082585 -
Total Health Improvement Program Research Project
|
||
Recruiting |
NCT05121337 -
Groceries for Black Residents of Boston to Stop Hypertension Among Adults Without Treated Hypertension
|
N/A | |
Withdrawn |
NCT04922424 -
Mechanisms and Interventions to Address Cardiovascular Risk of Gender-affirming Hormone Therapy in Trans Men
|
Phase 1 | |
Active, not recruiting |
NCT05062161 -
Sleep Duration and Blood Pressure During Sleep
|
N/A | |
Completed |
NCT05087290 -
LOnger-term Effects of COVID-19 INfection on Blood Vessels And Blood pRessure (LOCHINVAR)
|
||
Not yet recruiting |
NCT05038774 -
Educational Intervention for Hypertension Management
|
N/A | |
Completed |
NCT05621694 -
Exploring Oxytocin Response to Meditative Movement
|
N/A | |
Completed |
NCT05688917 -
Green Coffee Effect on Metabolic Syndrome
|
N/A | |
Recruiting |
NCT05575453 -
OPTIMA-BP: Empowering PaTients in MAnaging Blood Pressure
|
N/A |