The Potential Role of Testosterone on Target Organ Damage in Postmenopausal Hypertensive Women

Hypertension Clinical Trial

Official title:

The Potential Role of Testosterone Between Hypertension and Target Organ Damage in Postmenopausal Hypertensive Women

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT03451747
• Other study ID #: LanZhou
• Status: Not yet recruiting
• Phase: N/A
• First received: February 18, 2018
• Last updated: March 1, 2018
• Start date: March 10, 2018
• Est. completion date: April 5, 2018

Study information

• Verified date: January 2018
• Source: LanZhou University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The incidence of CVD-related deaths is generally higher in women than men. Postmenopausal changes in estrogen/androgen ratio that induce a relative androgen excess have been proposed as important factors in the higher prevalence of hypertension. Therefore, the investigators hypothesize that testosterone has potential role between hypertension and target organ damage in postmenopausal hypertensive women. And the objective is to evaluate the effects of testosterone between hypertension and target organ damage in postmenopausal hypertensive women.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 322
• Est. completion date: April 5, 2018
• Est. primary completion date: April 5, 2018
• Gender: All
• Age group: 45 Years to 65 Years

Eligibility

Inclusion Criteria:

• Clinical diagnosis of hypertension

• Women are all postmenopausal

• Men are matched with women.

Exclusion Criteria:

• Secondary hypertension

• Coronary disease

• Heart failure

• Arterial fibrillation

• Previous myocardial infarction

• Previous stroke

• Malignant disease

• Kidney failure

• Liver failure

• Neoplastic disease

• Severe neurological diseases

• Severe metabolic or organic decompensation

• Refuse to sign the informed consent form

Related Conditions & MeSH terms

• Hypertension

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
LanZhou University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Relative indexes of myocardial remodeling	Cardiac structure (left ventricular mass index in grams for square meter) measurement.	Baseline
Primary	Ambulatory blood pressure monitoring	Non-invasive ambulatory blood pressure monitoring (ABPM) was performed for every enrolled patient with an ABPM equipment.	Baseline
Primary	The level of testosterone (T)	Blood samples used to analyze the levels of sexual hormones were collected between morning 8:00 and 9:00 after an overnight fast. Testosterone (T) units on nanogram per deciliter.	Baseline