Hypertension Clinical Trial
Official title:
Effect of Endothelin Receptor Blocker Tracleer on Toruniquet-associated Hypertension During Total Knee Arthroplasty
Tourniquet is widely used in orthopedic surgery. However, prolonged tourniquet inflation may
cause a gradual rise in blood pressure, which named as tourniquet-associated hypertension.
Thus, to effectively prevent the tourniquet related hemodynamic responses is important for
patients receiving limb surgery.
Tracleer is an endothelin receptor antagonist indicated for the treatment of pulmonary
arterial hypertension. Tracleer can also be used to treat retistant hypertension. At present
trial, the investigators are going to investigate the effect of Tracleer on
tourniquet-associated hypertension during total knee arthroplasty.
At present study, the investigators will use endothelin receptor antagonist, Tracleer (Bosentan), to investigate the effect of Tracleer on tourniquet-associated hypertension during unilateral total knee arthroplasty, and evaluate its safety and effectivity. The purpose of this study is to find a new therapy to prevent and treat tourniquet-associated hypertension. ;
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