Hypertension Clinical Trial
Official title:
Double-Blind, Randomized, Cross-Over Trial of Aged Garlic Extract for Hypertension
The primary objective of this trial is to assess the effect of consumption of aged garlic
extract powder on 24 h systolic and diastolic ambulatory blood pressure in hypertensive
individuals following 8 weeks of supplementation.
Additional secondary objectives are to assess the effects of aged garlic extract powder
intake for 8 weeks on lipid profile (TC, HDL-C, LDL-C, and TG concentrations), blood glucose,
office blood pressure, pulse-wave velocity and augmentation index, body mass index, and waist
and hip circumference.
Forty hypertensive volunteers between 18 and 75 years will be recruited from the Winnipeg
(Manitoba, Canada) area to participate in a two arm crossover, double-blind, randomized,
placebo-controlled intervention study for 8 weeks per study period following obtainment of
informed consent.
The 2 periods of treatment will include:
1. Treatment period: One capsule twice a day, providing 600 mg each of aged garlic extract
powder, for a total of 1200 mg/day of aged garlic extract powder.
2. Control period: The control product will be an identical-looking placebo capsules
containing cellulose, which is being used as a filler in the treatment capsules.
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