Hypertension Clinical Trial
Official title:
Autonomic and Hemodynamic Responses to Inspiratory Muscle Exercise in Pre Hypertensive and Hypertensive Individuals: a Randomized Clinical Trial
This study aims to evaluate the autonomic and hemodynamic responses triggered by inspiratory muscle exercise in prehypertensive and hypertensive individuals. The reason that leads us to this study refers to clinical relevance for individuals with high blood pressure levels, since this type of exercise can act as a important nonpharmacological agent for arterial pressure control. In addition, this study aims to elucidate the mechanisms involved in cardiovascular responses to inspiratory muscle exercise and, consequently, provide safety in the prescription of these for this population.
This is a randomized clinical trial, consisting of a convenience sample of patients from the
Cardiology Department of the University Hospital (UH) of the Federal University of Juiz de
Fora (FUJF). The patients will be invited to participate in the study and will receive
information regarding the objectives and procedures of the study. In case of agreement with
their inclusion in the study, they will sign a free and informed consent form.
The entire experiment will be carried out in the Physical Evaluation Laboratory of the
UH-FUJF, by the researchers previously trained in the application of the protocol. The stages
of the experimental protocol will be divided into three days as described below.
1. 1st day of the experimental protocol (initial evaluation): medical historical,
anthropometric evaluation, electrocardiographic monitoring at rest, evaluation of
respiratory muscle strength and familiarization with the muscle training device. All
volunteers will be instructed to refrain from taking caffeinated and alcoholic beverages
for 24 h before the evaluation and to have a good night's sleep.
2. 2nd and 3rd days of the experimental protocol: all volunteers will be randomly assigned
to two exercise sessions (ES): Sham IME (no load) and moderate intensity IME (40% of
MIP). Initially, the volunteers will perform a 10-minute supine rest for heartbeat
collection and subsequent calculation of heart rate variability (HRV), blood pressure
and forearm blood flow measurements and evaluation of the baroreflex system. In sequence
the ES will be conducted with continuous monitoring of blood pressure, heart rate and
subjective perception of effort through the Borg Scale. Immediately and until one hour
after the ES, it will be measured forearm blood flow, blood pressure, heart rate and
evaluated the baroreflex system and HRV in order to investigate the acute effect of ES.
The volunteers will be monitored using an equipment capable of evaluating the outpatient
measurement of blood pressure and electrocardiogram for 24 hours in order to investigate
the chronic effect of ES.
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