Postprandial Effects of a High Potassium Meal

Hypertension Clinical Trial

Official title:

Postprandial Physiological Effects of a High Potassium Meal in Patients With Hypertension

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02959931
• Other study ID #: MSH 13-0088-A
• Status: Completed
• Phase: N/A
• Start date: June 2013
• Est. completion date: December 2014

Study information

• Verified date: February 2020
• Source: Samuel Lunenfeld Research Institute, Mount Sinai Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The investigators aim to evaluate the acute effects of potassium supplementation achieved by ingestion of potassium rich food, on vascular health.

Description:

Many studies have shown that an increase in potassium through the diet or through potassium pills helps to lower blood pressure. Also, the amount of oral potassium taken can improve how well the participants blood vessels work. These studies have focused on potassium given in the form of a pill. The investigators are interested in the effect of potassium consumed through food sources and how it will effect arterial health and blood pressure. The world health organization (WHO) recommends a K⁺ intake of at least 3510 mg/day from food for adults, excluding those with impaired K⁺ excretion. In this study the investigators aim to provide approximately 75% (approximately 2000 mg) of the total daily recommended intake for potassium in one meal. The investigators do not know whether dietary potassium (not pill form) will acutely improve the arterial health and if it will cause a decrease in blood pressure. The investigators hypothesis to see an improvement in vascular function following a high potassium meal compared to a low potassium meal.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 33
• Est. completion date: December 2014
• Est. primary completion date: December 2014
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• 18-80 years

• Normal sinus rhythm

• A diagnosis of hypertension on medical therapy with an ambulatory systolic blood pressure <160 mmHg and diastolic blood pressure <90 mmHg, or a diagnosis of stable coronary artery disease

Exclusion Criteria:

• Recent hospital admission due to an cardiovascular events

• Serum K+ concentration >5.0 mmol/L

• Current smoking

• Women who are pregnant

• Diabetic patients - patients receiving insulin therapy

• Glomerular filtration rate < 90mls/min/1.73m2

• On loop diuretic therapy

• Food allergies and/or intolerance to meal items

Related Conditions & MeSH terms

• Hypertension

Intervention

Other:
• High Potassium Meal
Breakfast meal that provides ~2400 mg of dietary potassium. Meals are isocaloric.
• Low Potassium Meal
Breakfast meal that provides ~540 mg of potassium. Meals are isocaloric.

Locations

Country	Name	City	State
Canada	Mount Sinai Hospital	Toronto	Ontario

Sponsors (1)

Lead Sponsor	Collaborator
Samuel Lunenfeld Research Institute, Mount Sinai Hospital

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in Flow Mediated Dilatation	Flow Mediated Dilatation is a method used to measure endothelial-dependent regulation of conduit artery tone(Joannides R, 1995).	Flow Mediated Dilatation will be assessed over 2 clinic visits, at 3 times points with in each visit; pre-prandial and post-prandial at 60 min and 120 min