Hypertension Clinical Trial
Official title:
A Prospective Multicenter Randomized Controlled Trial of Efficacy and Safety of Renal Denervation for Resistant Hypertension
Hypertension represents a significant global public health problem, contributing to vascular
and renal morbidity, cardiovascular mortality, and economic burden. For a mostly
asymptomatic disease, there is a huge challenge to maintain a good adherence and longtime
persistence of drug use so as to adequately control it. Even so, a significant proportion of
patients will develop resistant hypertension. In recent years, renal denervation has been
argued as an effective means to address blood pressure problem in several non-Chinese
clinical trials. The technique is to deliver low level radiofrequency energy through the
renal artery wall to target the sympathetic nervous system and then modulate blood pressure.
Shanghai WiseGain Medical Devices Co., LTD has developed the WiseGo Catheter System, which
is an irrigated radiofrequency ablation Catheter. With this Catheter, it is expected to
improve blood pressure status among patients with resistant hypertension failing
polypharmacy. The purpose of this randomized control trial is to obtain an assessment of the
efficacy and safety of WiseGo renal denervation technique in the presence of three standard
antihypertensive medications in Chinese patients.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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