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Chronic Clinical Effect of Acetazolamide — ChronicAZA  

Hypertension, Pulmonary Clinical Trial

Official title:
Chronic Clinical Effect of Acetazolamide in Pulmonary Hypertension

Clinical Trial Summary

The study seeks primarily to determine the chronic clinical effect of AZA on exercise capacity (6MWD) compared to placebo.

Clinical Trial Description

Pulmonary hypertension (PH) of various etiologies causes dyspnea, impairs exercise performance and is associated with reduced quality of life (QoL) and survival. Treatment options include therapy for any underlying causes, pulmonary vasodilator drugs, oxygen and, in selected cases, pulmonary endarterectomy or lung transplantation. Unfortunately, PH specific drugs are expensive, associated with side effects and even combined pharmacological treatment is often not sufficient to achieve clinical benefits. Therefore, novel therapeutic drugs are needed. We have recently demonstrated that sleep related breathing disorders, which are common in PH patients, can be improved by both nocturnal oxygen therapy and acetazolamide (AZA). AZA is a carbonic anhydrase (CA) inhibitor that acts as a respiratory stimulant thereby improving oxygenation and possibly PH. There are even data suggesting that CA-inhibitors have a direct pulmonary vasodilator effect. However, the potential role of AZA in the treatment of PH has not been conclusively studied. Therefore, the purpose of the current project is to investigate, the chronic clinical effects of AZA in PH patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02755298
Study type Interventional
Source University of Zurich
Contact
Status Completed
Phase Phase 2/Phase 3
Start date October 2016
Completion date November 2020
View Details
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