A Trial of Daily Ultraviolet Therapy to Reduce Cardiovascular Risk Factors

Status Terminated

Clinical Trial Summary

The investigators have shown that a single dose of ultraviolet irradiation (as found in sunlight) will lower blood pressure for around one hour. They are now testing whether daily UVA for two weeks will produce a sustained fall in BP in patients with high blood pressure. They will also measure the effect of daily UVA on other cardiovascular risk factors.

Clinical Trial Description

Epidemiological studies suggest that sunlight reduces all cause mortality, and particularly cardiovascular mortality. The investigators have previously shown vasodilatation and a transient fall in blood pressure following irradiation of human volunteers with 2 standard erythemal doses of UVA radiation. This was independent of vitamin D and temperature rise and correlated with a nitric oxide synthase independent mobilisation of NO stores from the skin to the systemic circulation. In this randomised, sham-controlled, cross-over double blind study, they will measure whether twice daily UVA administration can produce a sustained fall in BP and other cardiovascular risk factors in a cohort of pre-hypertensive patients. ;

Study Design

Related Conditions & MeSH terms

Hypertension

Clinical Trial Details

NCT number	NCT02621866
Study type	Interventional
Source	University of Edinburgh
Contact
Status	Terminated
Phase	N/A
Start date	May 2, 2017
Completion date	August 31, 2019

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