Hypertension Clinical Trial
Official title:
CPAP Effect on Nocturnal Evolution of Chemosensitivity Determinants in Sleep Apnea-hypopnea Patients With Isolated Nocturnal Hypertension or Day-nigh Sustained Hypertension
Study objective: To assess the nocturnal changes in mechanosensitivity and chemosensitivity
in hypertensive sleep apnea-hypopnea syndrome (SAHS) patients and in SAHS patients with
isolated nocturnal hypertension. To value the continuous positive airway pressure (CPAP)
effect on these parameters.
Design: Controlled cross-over longitudinal study. Settings: Madrid metropolitan area.
Patients: Day-night sustained hypertensive and isolated nocturnal hypertensive patients with
SAHS without previous treatment. At least 30 patients are needed.
Interventions: Patients will allocate in each treatment arm (CPAP vs. sham CPAP) during
three months. Explorations will perform before and immediately after sleep at 0-, 3-, and
6-months of trial.
Measurements: 24-h urinary catecholamine, local vascular factors, angiotensin and
aldosterone levels. Diaphragmatic tension-time index, metabolic rate, hypoxic withdrawal
test, and ventilatory and inspiratory neural drive responses to progressive isocapnic
hypoxia.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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