Hypertension Clinical Trial
Official title:
Treatment of Hypertension: an Interventional Approach to Improve Blood Pressure Control
The purpose of the study is to access the change in mean daytime systolic blood pressure in participants with essential hypertension not adequately controlled (defined as mean systolic daytime ambulatory blood pressure ≥ 135 mmHg) and randomly assigned to either an intervention group with one-time only Direct Observed Therapy (DOT) immediately followed by ABPM or a control group with standard ABPM.
More than 1 billion people world wide suffer from hypertension (HT), leaving it the world´s
top rank risk factor and contributor to global disease burden. Cardiac disease, stroke,
kidney disease and dementia are diseases related to HT with high economic burden on societies
and each year 9.4 million people die as a direct consequence of HT.
Estimated < 50 % of hypertensive patients adhere to preventive hypertensive medication after
1 year of treatment.
Poor adherence to antihypertensive treatment have by many been explained partly by the silent
nature of hypertension, the risk of side effects from antihypertensive medication, treatment
expenditures and the patient health perspectives.
In a randomized controlled trial design we plan to enrol 20 subjects, the limited number
explained by the study being part of the initial planning of a larger scale trial organized
by the research group, to invistigate the change in ambulatory bloodpressure with or with out
Direct Observed Theraphy prior to meassurement, as a one-time-only medication adherence
check.
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