Hypertension Clinical Trial
Official title:
Renal Sympathetic Denervation as a New Treatment for Therapy Resistant Hypertension - A Multicenter Randomized Controlled Trial
The aim of this study is to assess whether renal denervation (RD) added to usual care
compared to usual care alone reduces blood pressure (BP) as determined with ambulatory BP
monitoring (ABPM) after 6 months in subjects with an average day-time systolic BP of at
least 135 mmHg as determined with use of ABPM, despite use of three or more BP lowering
agents or with documented intolerance or contraindication for to 2 or more of the 4 major
classes of antihypertensive drugs (ACEi/ARB, calcium channel blockers, betablockers and
diuretics) obstructing use of 3 antihypertensives
Further aims are to assess the effect of renal denervation on the use of BP lowering agents,
to explore the effect of renal denervation in strata of estimated glomerular filtration rate
(eGFR) (eGFR 20-60 mL/min per 1.73m2 and eGFR>60 mL/min per 1.73m2) and according to
baseline office BP.
Randomization will be stratified by hospital and eGFR and will be at a 2:1 ratio.
n/a
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