Hypertension Clinical Trial
Official title:
Adjunct Vitamin D Therapy as a Means to Reduce the Disparity in Subclinical Target Organ Cardiac Damage Among Vulnerable Hypertensive Patients
This project seeks to reduce the disparity in hypertensive heart disease which exists for
African-Americans who have poorly controlled hypertension (HTN), also known as blood
pressure (BP). The investigators are targeting a highly vulnerable, often neglected subject
population which stands to benefit tremendously from better BP control and a corresponding
decrease in heart damage. HTN occurs early in life and more often in African-Americans,
reducing both quality and quantity of life. Inner-city African-Americans with HTN utilize
the emergency department (ED) for chronic BP management. Like cardiovascular disease,
vitamin D deficiency disproportionately affects African-Americans. Vitamin D is thought to
play an important role in cardiovascular health. Vitamin D replacement in those who are
deficient has been thought to reduce the cardiovascular disease, especially if initiated
early before irreversible damage has occurred, but this has yet to be tested in a
prospective clinical trial. Accordingly, this proposal was designed to investigate the
relationship between vitamin D and cardiac damage (as identified on cardiac magnetic
resonance imaging) in a cohort of African-American, vitamin D deficient hypertensive
patients without prior history of heart disease.
The primary objective of this proposal is to evaluate the efficacy of vitamin D therapy in
vitamin D deficient African-Americans with HTN. Vitamin D is an inexpensive treatment,
which, if shown to be effective could improve the existing approach to a widely accessible,
cost-effective option.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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