Does Administration of Etomidate and Propofol of the Anesthetic Induction of Elderly Hypertensive Patient Provide Superior Blood Pressure Stability in Response to Direct Laryngoscopy When Compared to Propofol or Etomidate Alone?

Hypertension Clinical Trial

Official title:

Does Administration of Etomidate and Propofol if the Anesthetic Induction of the Elderly Hypertensive Patient Provide Superior Blood Pressure Stability in Response to Direct Laryngosacopy, When Compared to Propofol or Etomidate Alone?

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT01248234
• Other study ID #: 2010-0097
• Status: Withdrawn
• Phase: Phase 3
• First received: November 23, 2010
• Last updated: July 12, 2012
• Start date: July 2012
• Est. completion date: July 2012

Study information

• Verified date: July 2012
• Source: University of Mississippi Medical Center
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

This study will attempt to show that a combination of drugs, Etomidate and Propofol, provide a more stable blood pressure when used to put elderly hypertensive patients to sleep than either drug used alone.

Description:

Same as above.

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: July 2012
• Est. primary completion date: July 2012
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 65 Years to 90 Years

Eligibility

Inclusion Criteria:

• Patients at least 65 years old, with a history of hypertension.

Exclusion Criteria:

• Patients less than 65 years old or without a history of hypertension.

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label

Related Conditions & MeSH terms

• Hypertension

Intervention

Drug:
• propofol
Propofol 1mg/kg will be given once to put the patient to sleep for surgery.
• Etomidate
Etomidate 0.3mg/kg will be given once to put the patient to sleep for surgery.
• Propofol and Etomidate
Etomidate 0.2mg/kg plus Propofol 0.5mg/kg will be given once to put the patient to sleep for surgery.

Locations

Country	Name	City	State
United States	University of Mississippi Medical Center	Jackson	Mississippi

Sponsors (1)

Lead Sponsor	Collaborator
University of Mississippi Medical Center

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Blood pressure stability during anesthetic induction	Blood pressure will be measures every minute for 15 minutes following anesthetic induction	15 minutes	Yes