Hypertension Clinical Trial
Official title:
The "ALiskiren or Losartan Effects on bioMARKers of Myocardial Remodeling (ALLMARK)" Study
The purpose of this study is to assess efficacy of aliskiren for reducing circulating levels of biomarkers of left ventricular (LV) remodeling associated with LV hypertrophy (LVH) in hypertensive patients.
Blood pressure was measured 10 weeks after starting treatment (visit 3). All patients who
did not achieve the required blood pressure (<140/90 mmHg) after 8 weeks of treatment at the
maximum doses of study medication were given 5 mg of amlodipine in addition to the study
medication in order to reach the required BP (<140/90 mmHg).
The patient's blood pressure was assessed at visit 4 (week 18) and if it was still not at
the required level (<140/90 mmHg), the dose of amlodipine was increased to 10 mg.
Blood pressure was again assessed at visit 5 (week 26) and if the required values had not
been reached (<140/90 mmHg), a 12.5 mg dose of hydrochlorothiazide (HCTZ) was prescribed
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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