SAPPHIRe III in Taiwan－Progression Evaluation & Cardiovascular Outcomes of

Status Active, not recruiting

Clinical Trial Summary

The purpose of this study is to determine the progression evaluation, cardiovascular outcomes, and genetic determinations of hypertension in Chinese

Clinical Trial Description

Blood pressure is a quantitative trait affected by both genetic and environmental factors. Stanford-Asian Pacific Program in Hypertension and Insulin Resistance (SAPPHIRe) is an international genetic study, which intends to map the major genetic loci underlying hypertension in sibpairs of Asian-Pacific Chinese and Japanese origin.

Success in genetic studies may depend on many factors including the selection of the patient population, the identification of intermediate phenotypes, the disease subsets, and the genetic strategy and methodologies employed.

In order to reduce heterogeneity of the genetic and environmental background, we will focus our investigation on the Chinese population. Furthermore, besides the variables associated with insulin resistance, which were collected and studied in year 1 through 5 of SAPPHIRe, some more variables from echocardiographic examination and multi-detector row computed tomography (MDCT) will be collected and studied.

Hypertension is a major risk factor for stroke, myocardial infraction and renal disease. Hypertension often occurs in combination with other metabolic complications such as hyperlipidemia, obesity and insulin resistance. The combined disorder is often called the metabolic syndrome.

Our general approach is to continue analyzing candidate genes as well as perform a complete genome search based on the exiting genome-wide scan data together with old and new phenotype variables. Our objective is to identify susceptible gene for hypertension through incorporating intermediate phenotypes and to find gene markers for developing useful screening tools for the high risk group in order to prevent or early detect cardiovascular disorder patients. ;

Study Design

Observational Model: Family-Based, Time Perspective: Retrospective

Related Conditions & MeSH terms

Hypertension

Clinical Trial Details

NCT number	NCT00631956
Study type	Observational
Source	National Health Research Institutes, Taiwan
Contact
Status	Active, not recruiting
Phase	N/A
Start date	October 2006
Completion date	December 2016

View Details

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

SAPPHIRe III in Taiwan－Progression Evaluation and Cardiovascular Outcomes of Hypertensive Families

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms