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NCT00538044 Clinical Trial

Simvatstatin Used to Treat Pulmonary Hypertension

Hypertension, Pulmonary Clinical Trial

Official title:
the Clinical Research Using Simvastatin as a Medication to Treat Advanced Secondary Pulmonary Hypertension

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT00538044
Other study ID # Gan1
Secondary ID Anzhen1
Status Not yet recruiting
Phase Phase 1
First received October 1, 2007
Last updated October 1, 2007
Start date January 2009
Est. completion date January 2012

Study information
Verified date September 2007
Source Capital Medical University
Contact Huili Gan, MD,Ph.D.
Phone 13001277863
Email ganhuili@hotmail.com
Is FDA regulated No
Health authority China: Ethics Committee
Study type Interventional

Clinical Trial Summary

we try to use simvastatin in the treatment of advanced pulmoary hypertension secondary to congenital heart disease or chronic pulmonary embolism before and after the operation.

Description:

advanced pulmonary hypertension is refractory to the medication in use nowaday, especially pulmonary hypertension secondary to congenital heart disease or chronic pulmonary embolism.It is revealed that statins may intefere the pathogenisis of the pulmonary hypertension in many key poing, such as improving apotosis or inhiting the proliferation of pulmonary vascular smooth muscle cell. so we try to use simvastatin in the treatment of advanced pulmoary hypertension secondary to congenital heart disease or chronic pulmonary embolism before and after the operation.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 0
Est. completion date January 2012
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 12 Years to 70 Years
Eligibility Inclusion Criteria:

- pasp>50mmHg

Exclusion Criteria:

- pasp<50mmhg

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

Intervention

Drug:
• simvastatin
medication with simvastation on the dosage of 40mg per day before the operation and all the time after the operation

Locations
Country Name City State
China Beijing Anzhen Hospital Beijing

Sponsors (1)
Lead Sponsor Collaborator
Capital Medical University

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary the simvastatin can alleviate pulmonary hypertension
Primary pulmonary pressure
Secondary simvastatin can highten the perioperative and long term survaval rate and the living quality
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