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NCT00497016 Clinical Trial

Does Statin Therapy Reduce Sympathoexcitation in Hypertension?

Hypertension Clinical Trial

Official title:
Does Statin Therapy Reduce Sympathoexcitation in Hypertension?

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00497016
Other study ID # HTSTAT
Secondary ID
Status Completed
Phase N/A
First received July 4, 2007
Last updated September 29, 2008
Start date May 2007
Est. completion date March 2008

Study information
Verified date September 2008
Source Radboud University
Contact n/a
Is FDA regulated No
Health authority Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)
Study type Interventional

Clinical Trial Summary

A number of patients with hypertension have increased central sympathetic activity. Statins seem to inhibit central sympathetic output. This study assesses the effect of statins on central sympathetic activity in hypertension patients.

Recruitment information / eligibility
Status Completed
Enrollment 13
Est. completion date March 2008
Est. primary completion date
Accepts healthy volunteers
Gender Both
Age group 18 Years to 70 Years
Eligibility Inclusion Criteria:

- (Known) hypertension

- stable drug therapy for at least 2 months

- age 18-70 jaar

- BMI 18-35 kg/m2

- Sinusrhythm

Exclusion Criteria:

- Recent cardiovascular event <6 mnd

- Plasma Creatinin:

- female: >120 mmol/L

- male: >133 mmol/L

- use of:

- tricyclic antidepressants

- alpha-1 -and/or alpha-2 blockers

- disease of the autonomic nervous system (Parkinsons disease, Shy- Drager syndrome, etc)

- Albuminuria >300 mg/dag

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double-Blind

Related Conditions & MeSH terms

Intervention

Drug:
• atorvastatin 80 mg

Locations
Country Name City State
Netherlands Radboud University Medical Center Nijmegen NIjmegen

Sponsors (2)
Lead Sponsor Collaborator
Radboud University ZonMw: The Netherlands Organisation for Health Research and Development

Country where clinical trial is conducted

Netherlands, 

Outcome
Type Measure Description Time frame Safety issue
Primary change in central sympathetic activity
Secondary change in cholesterol levels, renin and aldosteron
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