Hypertension Clinical Trial
Official title:
Study on Optimal Anti-hypertensive Therapy With Valsartan by Using Home Blood Pressure Measurement
The purpose of this study is to compare improvement percentage of urinary albumin excretion between valsartan 80 mg- and valsartan 160 mg-based therapy in patient with morning hypertension.
The cardiovascular diseases such as stroke and myocardial infarction consist 50% of the
cause of death in Japanese population. Numerous mega trials have shown that strict
anti-hypertensive therapy could reduce cardiovascular morbidity and mortality in
hypertensive patients.
It is reported, however, over 50% hypertensive patients have not been controlled below
therapeutic target blood pressure that the JSH2004 guideline recommends.
Recently use of Angiotensin II receptor blockers (ARBs) is increasing progressively for
their pharmacological action on organ protection as well as potent reduction in blood
pressure. However, usual dosage of ARB in Japan is almost half of that in the mega trials
executed in Europe and America. Lower dosage compared to western countries might be a reason
why cardiovascular events are not fully reduced in Japan.
Valsartan optimal therapy against elevated home blood pressure research (VOYAGER) study will
be a multi-center, open-label, randomized, active-controlled study to evaluate the
following; improvement percentage of urinary albumin exception, home blood pressure,
hospital blood pressure, incidence of stroke, cardiovascular disease, and microangiopathy
with valsartan 80 mg- or valsartan 160 mg based therapy in patients with elevated morning
home blood pressure.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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