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NCT00327431 Clinical Trial

Relationship of Genes and Life Events to Blood Pressure

Hypertension Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00327431
Other study ID # 1000009109
Secondary ID
Status Completed
Phase N/A
First received May 17, 2006
Last updated May 21, 2008
Start date November 2006
Est. completion date December 2007

Study information
Verified date May 2008
Source Sunnybrook Health Sciences Centre
Contact n/a
Is FDA regulated No
Health authority Canada: Ethics Review Committee
Study type Observational

Clinical Trial Summary

Research suggests that blood pressure is influenced by both genetic and environmental factors. The goal of this study is to find genes that play a role in blood pressure and understand how they interact with life events (such as job stress) to influence blood pressure. We hypothesize that the gene for endothelin-1 is associated with increased blood pressure. Further, we predict that this genetic relationship is moderated by psychosocial stress factors, specifically job strain and marital cohesion.

Recruitment information / eligibility
Status Completed
Enrollment 120
Est. completion date December 2007
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group N/A and older
Eligibility Inclusion Criteria:

- Previous participation in a study of psychosocial stressors and blood pressure (Double Exposure Study) and agreement to participate in follow-up studies

Exclusion Criteria:

- Withdrawal of consent

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

Intervention

Genetic:
• Cheek swab samples for DNA

Locations
Country Name City State
Canada Sunnybrook Health Sciences Centre Toronto Ontario

Sponsors (1)
Lead Sponsor Collaborator
Sunnybrook Health Sciences Centre

Country where clinical trial is conducted

Canada, 

References & Publications (1)

Tobe SW, Kiss A, Szalai JP, Perkins N, Tsigoulis M, Baker B. Impact of job and marital strain on ambulatory blood pressure results from the double exposure study. Am J Hypertens. 2005 Aug;18(8):1046-51. — View Citation

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