Hypertension Clinical Trial
Official title:
A Randomized, Placebo-Controlled, Double-Blind, Six-Arm, Dose Escalation, Multi-Center Study to Evaluate the Efficacy and Safety of SLV306: 150, 300, 600 mg Once Daily, 150-300 mg Twice Daily and Amlodipine 5-10 mg Once Daily in Subjects With Hypertension
This study is to compare the efficacy and safety of increasing doses of SLV306 with amlodipine.
Status | Completed |
Enrollment | 0 |
Est. completion date | |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - sitting office diastolic blood pressure between 90 and 109 mmHg - office systolic blood pressure between 140 and 179 mmHg - mean day-time diastolic 24-h ABPM blood pressure >= 85 mmHg inclusive at baseline Exclusion Criteria: - known secondary hypertension - decompensated congestive heart failure |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Australia | Site 705 | Bracken Ridge | |
Australia | Site 706 | Caboolture | |
Australia | Site 700 | Inala | |
Australia | Site 701 | Kippa Ring | |
Australia | Site 702 | Melbourne | |
Australia | Site 703 | Nedlands | |
Bulgaria | Site 952 | Haskovo | |
Bulgaria | Site 955 | Pleven | |
Bulgaria | Site 951 | Plovdiv | |
Bulgaria | Site 956 | Plovdiv | |
Bulgaria | Site 950 | Sofia | |
Bulgaria | Site 953 | Sofia | |
Bulgaria | Site 954 | Sofia | |
Bulgaria | Site 957 | Sofia | |
Denmark | Site 402 | Aalborg | |
Denmark | Site 401 | Ballerup | |
Denmark | Site 403 | Vejle | |
Estonia | Site 850 | Tallinn | |
Germany | Site 119 | Aschaffenburg | |
Germany | Site 101 | Bad Nauheim | |
Germany | Site 104 | Bad Woerishofen | |
Germany | Site 106 | Beckum | |
Germany | Site 110 | Deidesheim | |
Germany | Site 107 | Karlsruhe | |
Germany | Site 118 | Kassel | |
Germany | Site 109 | Krombach | |
Germany | Site 113 | Ladenburg | |
Germany | Site 102 | Leipzig | |
Germany | Site 112 | Lollar | |
Germany | Site 114 | Magdeburg | |
Germany | Site 111 | Marburg | |
Germany | Site 105 | Muenster | |
Germany | Site 115 | Niederstetten | |
Germany | Site 120 | Rodgau Dudenhofen | |
Germany | Site 116 | Vellmar | |
Germany | Site 103 | Wiesbaden | |
Germany | Site 117 | Wolmirstedt | |
Hungary | Site 800 | Budapest | |
Hungary | Site 805 | Budapest | |
Hungary | Site 803 | Gyongyos | |
Hungary | Site 801 | Kecskemet | |
Hungary | Site 804 | Pecs | |
Hungary | Site 802 | Szekesfehervar | |
Israel | Site 300 | Ashkelon | |
Israel | Site 306 | Ashkelon | |
Israel | Site 304 | Beer Sheva | |
Israel | Site 311 | Haifa | |
Israel | Site 305 | Jerusalem | |
Israel | Site 310 | Kfar Saba | |
Israel | Site 303 | Kiryat Ata | |
Israel | Site 308 | Petach-Tikva | |
Israel | Site 302 | Tel-Aviv | |
Israel | Site 301 | Tel-Hashomer | |
Israel | Site 309 | Tiberias | |
Latvia | Site 932 | Daugavpils | |
Latvia | Site 930 | Kuldiga | |
Latvia | Site 931 | Riga | |
Latvia | Site 933 | Riga | |
Latvia | Site 934 | Riga | |
Latvia | Site 935 | Riga | |
Lithuania | Site 920 | Kaunas | |
Lithuania | Site 923 | Klaipeda | |
Lithuania | Site 921 | Vilnius | |
Slovakia | Site 600 | Bratislava | |
Slovakia | Site 601 | Bratislava | |
Slovakia | Site 607 | Kosice | |
Slovakia | Site 608 | Kosice | |
Slovakia | Site 602 | Levice | |
Slovakia | Site 605 | Lucenec | |
Slovakia | Site 603 | Nove Zamky | |
Slovakia | Site 606 | Vrable | |
United Kingdom | Site 262 | Addlestone | |
United Kingdom | Site 229 | Airdrie | |
United Kingdom | Site 234 | Alexandria | |
United Kingdom | Site 245 | Bangor | |
United Kingdom | Site 241 | Barrhead | |
United Kingdom | Site 224 | Bath | |
United Kingdom | Site 240 | Bath | |
United Kingdom | Site 230 | Bellshill | |
United Kingdom | Site 261 | Bexhill on sea | |
United Kingdom | Site 243 | Bexhill- on-Sea | |
United Kingdom | Site 255 | Blackpool | |
United Kingdom | Site 222 | Blantyre | |
United Kingdom | Site 232 | Calderbank | |
United Kingdom | Site 236 | Chesterfield | |
United Kingdom | Site 219 | Chippenham | |
United Kingdom | Site 256 | Chippenham | |
United Kingdom | Site 237 | Co Tyrone | |
United Kingdom | Site 216 | Coatbridge | |
United Kingdom | Site 238 | Cornwall | |
United Kingdom | Site 207 | Coventry | |
United Kingdom | Site 247 | Cumbernauld | |
United Kingdom | Site 208 | Dumbarton | |
United Kingdom | Site 235 | East Horsley | |
United Kingdom | Site 220 | Ely | |
United Kingdom | Site 257 | Frome | |
United Kingdom | Site 210 | Glasgow | |
United Kingdom | Site 221 | Glasgow | |
United Kingdom | Site 227 | Glasgow | |
United Kingdom | Site 233 | Glasgow | |
United Kingdom | Site 251 | Glasgow | |
United Kingdom | Site 201 | Greenisland | |
United Kingdom | Site 252 | Helensburgh | |
United Kingdom | Site 249 | Hook | |
United Kingdom | Site 200 | Leamington SPA | |
United Kingdom | Site 226 | Maidenhead | |
United Kingdom | Site 246 | Maidenhead | |
United Kingdom | Site 213 | Manchester | |
United Kingdom | Site 244 | Melksham | |
United Kingdom | Site 259 | Middlesex | |
United Kingdom | Site 202 | Motherwell | |
United Kingdom | Site 206 | Motherwell | |
United Kingdom | Site 217 | Motherwell | |
United Kingdom | Site 239 | Motherwell | |
United Kingdom | Site 231 | Paisley | |
United Kingdom | Site 250 | Paisley | |
United Kingdom | Site 242 | Penzance | |
United Kingdom | Site 218 | Plymouth | |
United Kingdom | Site 223 | Plymouth | |
United Kingdom | Site 254 | Reading | |
United Kingdom | Site 212 | Riddrie | |
United Kingdom | Site 253 | Sandy | |
United Kingdom | Site 258 | Sheffield | |
United Kingdom | Site 205 | Slough | |
United Kingdom | Site 215 | St Just | |
United Kingdom | Site 211 | Strathaven | |
United Kingdom | Site 225 | Swansea | |
United Kingdom | Site 209 | Thornhill | |
United Kingdom | Site 248 | Woking | |
United Kingdom | Site 228 | Wokingham |
Lead Sponsor | Collaborator |
---|---|
Solvay Pharmaceuticals |
Australia, Bulgaria, Denmark, Estonia, Germany, Hungary, Israel, Latvia, Lithuania, Slovakia, United Kingdom,
Status | Clinical Trial | Phase | |
---|---|---|---|
Terminated |
NCT04591808 -
Efficacy and Safety of Atorvastatin + Perindopril Fixed-Dose Combination S05167 in Adult Patients With Arterial Hypertension and Dyslipidemia
|
Phase 3 | |
Recruiting |
NCT04515303 -
Digital Intervention Participation in DASH
|
||
Completed |
NCT05433233 -
Effects of Lifestyle Walking on Blood Pressure in Older Adults With Hypertension
|
N/A | |
Completed |
NCT05491642 -
A Study in Male and Female Participants (After Menopause) With Mild to Moderate High Blood Pressure to Learn How Safe the Study Treatment BAY3283142 is, How it Affects the Body and How it Moves Into, Through and Out of the Body After Taking Single and Multiple Doses
|
Phase 1 | |
Completed |
NCT03093532 -
A Hypertension Emergency Department Intervention Aimed at Decreasing Disparities
|
N/A | |
Completed |
NCT04507867 -
Effect of a NSS to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III
|
N/A | |
Completed |
NCT05529147 -
The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail Elderly
|
||
Recruiting |
NCT05976230 -
Special Drug Use Surveillance of Entresto Tablets (Hypertension)
|
||
Recruiting |
NCT06363097 -
Urinary Uromodulin, Dietary Sodium Intake and Ambulatory Blood Pressure in Patients With Chronic Kidney Disease
|
||
Completed |
NCT06008015 -
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of "BR1015" and Co-administration of "BR1015-1" and "BR1015-2" Under Fed Conditions in Healthy Volunteers
|
Phase 1 | |
Completed |
NCT05387174 -
Nursing Intervention in Two Risk Factors of the Metabolic Syndrome and Quality of Life in the Climacteric Period
|
N/A | |
Completed |
NCT04082585 -
Total Health Improvement Program Research Project
|
||
Recruiting |
NCT05121337 -
Groceries for Black Residents of Boston to Stop Hypertension Among Adults Without Treated Hypertension
|
N/A | |
Withdrawn |
NCT04922424 -
Mechanisms and Interventions to Address Cardiovascular Risk of Gender-affirming Hormone Therapy in Trans Men
|
Phase 1 | |
Active, not recruiting |
NCT05062161 -
Sleep Duration and Blood Pressure During Sleep
|
N/A | |
Completed |
NCT05087290 -
LOnger-term Effects of COVID-19 INfection on Blood Vessels And Blood pRessure (LOCHINVAR)
|
||
Not yet recruiting |
NCT05038774 -
Educational Intervention for Hypertension Management
|
N/A | |
Completed |
NCT05621694 -
Exploring Oxytocin Response to Meditative Movement
|
N/A | |
Completed |
NCT05688917 -
Green Coffee Effect on Metabolic Syndrome
|
N/A | |
Recruiting |
NCT05575453 -
OPTIMA-BP: Empowering PaTients in MAnaging Blood Pressure
|
N/A |