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NCT00141583 Clinical Trial

The Renin-Angiotensin System in Essential Hypertension

Hypertension Clinical Trial

Official title:
The Renin-Angiotensin System in Essential Hypertension

Clinical Trial Details — Status: Terminated

Administrative data
NCT number NCT00141583
Other study ID # LREC 01.87.10
Secondary ID
Status Terminated
Phase N/A
First received August 31, 2005
Last updated June 5, 2015
Start date April 2004
Est. completion date October 2006

Study information
Verified date May 2007
Source St George's, University of London
Contact n/a
Is FDA regulated No
Health authority United Kingdom: Research Ethics Committee
Study type Interventional

Clinical Trial Summary

Although ACE Inhibitors and Angiotensin Receptor Blockers are effective blood pressure lowering agents, the exact mechanisms by which these agents lower BP are still not fully understood. This study aims to compare the blood pressure and hormonal responses (plasma renin activity and aldosterone) to the ACE inhibitor enalapril and ARB candesartan in individuals with mild essential hypertension.

Recruitment information / eligibility
Status Terminated
Enrollment 11
Est. completion date October 2006
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 70 Years
Eligibility Inclusion Criteria:

- Essential Hypertension

- SBP 140-159 mmHg

- DBP 90-99 mmHg

Exclusion Criteria:

- Intolerance of or allergy to ACE Inhibitors or ARBS

- Pregnant or Breastfeeding

- Pre-menopausal women

- Uncontrolled cardiac or renal failure

- Diabetes mellitus

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label

Related Conditions & MeSH terms

Intervention

Drug:
• Enalapril 20 mg bd

• Candesartan 8 mg bd

Locations
Country Name City State
United Kingdom Blood Pressure Unit, Dept. Cardiac & Vascular Sciences, SGUL London

Sponsors (1)
Lead Sponsor Collaborator
St George's, University of London

Country where clinical trial is conducted

United Kingdom, 

Outcome
Type Measure Description Time frame Safety issue
Primary Change in BP
Primary Change in PRA and aldosterone
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