Clinical Trials Logo
  1. Home
  2. Hyperparathyroidism, Primary
  3. NCT00975221

Efficacy and Safety Study of Cinacalcet for the Treatment of Hypercalcemia in Patients With Primary Hyperparathyroidism Unable to Undergo Parathyroidectomy

Hypercalcemia Clinical Trial

Official title:
A Randomized Double-blind Placebo-controlled Study to Evaluate the Efficacy and Safety of Cinacalcet for the Treatment of Hypercalcemia in Subjects With Primary Hyperparathyroidism Unable to Undergo Parathyroidectomy

Clinical Trial Summary

This study is designed to demonstrate the efficacy and to assess the safety of cinacalcet for the reduction of hypercalcemia in patients with primary hyperparathyroidism for whom parathyroidectomy is indicated on the basis of an elevated corrected total serum calcium, but who are unable to undergo parathyroidectomy.

Clinical Trial Description

The study will consist of a 30-day screening phase, a 12-week placebo-controlled dose-titration phase, and a 16-week placebo-controlled efficacy assessment phase (EAP). Participants who complete 28 weeks on study will continue into an open-label safety extension phase for 24 weeks of investigational cinacalcet treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00975221
Study type Interventional
Source Amgen
Contact
Status Completed
Phase Phase 3
Start date March 10, 2010
Completion date December 21, 2012
View Details
See also
  Status Clinical Trial Phase
Withdrawn NCT02711059 - Insulin Resistance in Primary Hyperparathyroidism N/A
Recruiting NCT05585593 - Registry for Hypoparathyroidism Wuerzburg
Terminated NCT01725113 - Management of Mineral and Bone Disease in Hemodialysis-Calcitriol vs. Paricalcitol Phase 4
Completed NCT01460030 - An Intra-individual Titration Study of KRN1493 for the Treatment of Hypercalcemia in Patients With Parathyroid Carcinoma or Intractable Primary Hyperparathyroidism Phase 3
Completed NCT00325104 - Cinacalcet to Treat Familial Primary Hyperparathyroidism Phase 3
Recruiting NCT03935984 - Calcitonin Pre-treatment to Improve SPECT-CT Sensitivity Phase 4
Withdrawn NCT01329666 - Primary Hyperparathyroidism (PHPT): Early Effect of Vitamin D Phase 2/Phase 3
Completed NCT00891813 - Effectiveness and Safety of IV Zemplar in Patients on Hemodialysis and With Secondary Hyperparathyroidism Using iPTH/100 as Initial Dose Phase 4
Completed NCT00674154 - Effect of Vitamin D Treatment in Primary Hyperparathyroidism Phase 2/Phase 3
Completed NCT04299425 - Evaluating Impact of NIRAF Detection for Identifying Parathyroid Glands During Parathyroidectomy N/A
Withdrawn NCT03516747 - Preoperational Fine Needle Aspiration of Pathological Parathyroid Gland N/A
Completed NCT00485706 - Arterial Stiffness and Decreased Bone Buffering Capacity in Hemodialysis Patients N/A
Recruiting NCT01647503 - Differentially Expressed Proteins in Sporadic Parathyroid Tumors N/A
Completed NCT01042626 - Oral Peptones Load in Normocalcemic and Hypercalcemic Primary Hyperparathyroidism and Healthy Subjects N/A
Not yet recruiting NCT01021280 - Parathyroid Hormone (PTH) Homeostasis in Bartter Syndrome N/A
Not yet recruiting NCT01226810 - The Novel Approach of Minimally Invasive Parathyroid Surgery Requires Precise Identification and Localization of the Lesion Prior to Exploration N/A
Terminated NCT00415584 - Cinacalcet to Treat Hypercalcemia in Renal Transplant Recipients Phase 1/Phase 2
Completed NCT00581828 - Does Treatment of Hypovitaminosis D Increase Calcium Absorption? Phase 4
Completed NCT00126386 - Zometa for the Management of Tumor-induced Hypercalcemia and Malignant Bone Pain in the Community N/A
Recruiting NCT05152927 - Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Parathyroidectomy N/A